Community out-of-hours palliative care - 'It's a patchwork of services': A qualitative study exploring care provision.

Background: People in receipt of community palliative care usually receive care from a range of services and require access to care 24/7. However, care outside of normal working hours varies, with little understanding of which models of care are optimal.

Aim: To identify and characterise current models of out-of-hours community palliative care in the UK and explore healthcare professionals' views on the barriers and facilitators to providing high quality community out-of-hours care.

Human placental cells are resistant to SARS-CoV-2 infection and replication.

Background: Infection during pregnancy with SARS-CoV-2 can have a serious impact on both maternal and foetal health. Clinical studies have shown that SARS-CoV-2 transmission from the mother to the foetus typically does not occur. However, there is evidence that SARS-CoV-2 can infect the placenta .

Do anomalous aortic origin of a coronary artery patients have higher risk of myocardial ischaemia and adverse cardiac events during aortic and mitral valve replacements?

Objectives: We assessed the effect of anomalous aortic origin of a coronary artery on the risk of early and late postoperative events after aortic or mitral valve replacement in adults.

Methods: Between 2005 and 2022, 29,579 adults underwent surgical aortic or mitral valve replacement at Cleveland Clinic. Among these, 29 had an unrepaired coronary artery rising anomalously from the aorta that was not intervened upon during valve surgery, 19 (65%) an anomalous circumflex, and 9 (31%) an anomalous right.

Programmed ribosomal frameshifting during mRNA decoding generates a constitutively active mediator of kinesin-1-dependent lysosome transport.

Programmed ribosomal frameshifting is a translational recoding phenomenon in which a proportion of ribosomes are stimulated to slip backwards or forwards on an mRNA, rephasing the ribosome relative to the mRNA. While frameshifting is often employed by viruses, very few phylogenetically conserved examples are known in vertebrate genes and the evidence for some of these is controversial. Here we report a +1 frameshifting signal in the coding sequence of the human gene , encoding the ARL8-dependent, lysosome-kinesin-1 adaptor protein PLEKHM2.