Publications by authors named "A E Etkin"
Neuroimaging-based subtyping is increasingly used to explain heterogeneity in psychiatric disorders. However, the clinical utility of these subtyping efforts remains unclear, and replication has been challenging. Here we examined how the choice of neuroimaging measures influences the derivation of neuro-subtypes and the consequences for clinical delineation.
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- PTSD primarily affects females and is linked to altered brain connectivity, differing from previous findings in males.
- The study involved 61 women who had experienced trauma, utilizing resting EEG data to measure brain connectivity.
- Results indicated that women with PTSD showed increased connectivity in certain brain regions, particularly those related to visual processing and attention, with hormonal factors potentially influencing these patterns.
Neuroimaging and cognitive neuroscience studies have identified neural circuits linked to anxiety, mood, and trauma-related symptoms and focused on their interaction with the medial prefrontal default mode circuitry. Despite these advances, developing new neuromodulatory treatments based on neurocircuitry remains challenging. It remains unclear which nodes within and controlling these circuits are affected and how their impairment is connected to psychiatric symptoms.
View Article and Find Full Text PDFTowards a consensus roadmap for a new diagnostic framework for mental disorders.
Eur Neuropsychopharmacol
January 2025
Article Synopsis
- Current mental disorder classifications are based on convention and symptom clusters rather than biological mechanisms, leading to significant overlap and variability in diagnoses.
- There is a need for a new diagnostic framework that incorporates neurobiology to enhance treatment options and help patients better understand their illnesses.
- The ECNP New Frontiers Meeting 2024 aims to establish a roadmap for improved precision diagnostics by focusing on innovative technologies, the biology of mental illness, and translating this knowledge into effective treatment strategies.*
Cocaine use disorder (CUD) is prevalent, and repetitive transcranial magnetic stimulation (rTMS) shows promise in reducing cravings. However, the association between a consistent CUD-specific functional connectivity signature and treatment response remains unclear. Here we identify a validated functional connectivity signature from functional magnetic resonance imaging to discriminate CUD, with successful independent replication.
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