Effect of urea on the activity of certain ophthalmic drugs in man.

The role displayed by urea (2-10%) solutions, on the miotic and mydriatic activities of pilocarpine hydrochloride and homatropine hydrobromide respectively, was investigated on the human eye. At different concentrations, urea exerts no effect on the miotic activity of pilocarpine, whereas in the case of homatropine a negative effect is experienced. For the parameters, area under pupil diameter--time curve (AUC) and maximum pupillary response (MPR), a linear relationship exists between response to homatropine and urea concentration.

Quantitative Changes in Carbohydrates and Acidity during Manufacture of Low-Lactose Zabadi.

B-galactosidase from Saccharomyces lactis was used to hydrolyze lactose in buffalo milk from which Zabadi was made. The lactose content of Zabadi samples decreased with increasing the amount of β-galactosidase used for hydrolysis of the buffalo milk from which Zabadi was made. Also, higher product scores were given to Zabadi samples made from treated milk that contained 28.