Surveillance of laboratory exposures to human pathogens and toxins, Canada, 2023.

Background: The Public Health Agency of Canada oversees the and , and monitors human pathogen and toxin incidents in licensed facilities to minimize exposure impact at the individual and population level.

Objective: To provide an overview of confirmed laboratory exposure incidents in Canada in 2023.

Methods: Confirmed exposure incident reports in 2023 were analyzed using R 4.

Evaluating the effect of noise reduction strategies in CT perfusion imaging for predicting infarct core with deep learning.

This study evaluates the efficacy of deep learning models in identifying infarct tissue on computed tomography perfusion (CTP) scans from patients with acute ischemic stroke due to large vessel occlusion, specifically addressing the potential influence of varying noise reduction techniques implemented by different vendors. We analyzed CTP scans from 60 patients who underwent mechanical thrombectomy achieving a modified thrombolysis in cerebral infarction (mTICI) score of 2c or 3, ensuring minimal changes in the infarct core between the initial CTP and follow-up MR imaging. Noise reduction techniques, including principal component analysis (PCA), wavelet, non-local means (NLM), and a no denoising approach, were employed to create hemodynamic parameter maps.

Interactions of the Pneumococcus with the Central Nervous System: Postnatal Meningitis Versus Fetal Neurodevelopment.

In young children, pneumococcal meningitis epitomizes the paradigm of a destructive innate inflammatory response in the central nervous system: a five-alarm fire. In contrast, cell-free bacterial components reaching the fetal brain from an infected mother signal a quiet, noninflammatory immune response that drives abnormal neurodevelopment, changing brain architecture through neuroproliferation. This review addresses the difference between prenatal and postnatal bacterial-host signaling within the brain.