Objective: Circulating extracellular vesicles (EVs) have a great impact on human health as biomarkers and messengers in intercellular signalling. We aimed to determine how the miRNA profile of circulating EVs during an acute coronary event interferes with the vasculogenic potential of endothelial cells (EC).
Approach And Results: EVs were purified from the plasma of patients in the acute phase of non-ST segment elevation myocardial infarction (NSTEMI, n = 33) and from healthy donors (n = 19) used as a control group.
Reprod Domest Anim
March 2025
This study evaluated the effect of equine chorionic gonadotropin (eCG) on ovarian vascularisation and plasma progesterone (P4) levels in Murrah buffaloes during an ovulation synchronisation protocol. Twenty buffaloes were divided into two groups: with eCG (n = 20) and without eCG (control, n = 20) in a crossover design. A 1.
View Article and Find Full Text PDFBackground: Ineffective health maintenance behaviors (00292) is an important nursing diagnosis in the context of chronic conditions. However, it is observed that the etiology of this phenomenon is not well defined for this population. For nurses to infer this diagnosis early and, consequently, develop effective care plans, further studies are needed to facilitate the understanding of the factors related to the phenomenon.
View Article and Find Full Text PDFThis comprehensive review aims to provide a thorough overview of the vital role that extracellular vesicles (EVs) play in endothelial dysfunction, particularly emphasizing how physiological factors-such as sex and aging-along with significant cardiovascular risk factors, influence this process. The review covers studies ranging from the first description of EVs in 1945 to contemporary insights into their biological roles in intercellular signaling and endothelial dysfunction. A comprehensive analysis of peer-reviewed articles and reviews indexed in the PubMed database was conducted to compile the information.
View Article and Find Full Text PDFBackground: Systemic sclerosis (SSc) is a complex disease whose diagnosis is based on clinical manifestations, serological testing for autoantibodies, and nailfold capillaroscopy. Although some proteins have been proposed as biomarkers, the diagnosis of SSc remains a challenge for clinicians. The soluble oncostatin M receptor (sOSMR) is a potential biomarker for the diagnosis of SSc, as it appears to act as an antagonist of oncostatin M (OSM)-mediated signaling, which is involved in biological and inflammatory processes, including tissue injury and fibrosis.
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