Neoadjuvant treatment and survival outcomes by pathologic complete response in HER2-negative early breast cancers.

The benefit of pathologic complete response (pCR) in early breast cancer (eBC) is not well described in the real-world setting. This study used the nationwide Flatiron Health electronic health record-derived deidentified database to describe treatment patterns and survival outcomes by pCR status after neoadjuvant therapy (NAT) in women with triple-negative or HR/HER2 eBC. Observational cohort study analyzing women with eBC who started NAT between 2011 and 2018.

Use of scenario tree modelling to plan freedom from infection surveillance: Mycoplasma bovis in New Zealand.

Since mid-2018, the New Zealand (NZ) Ministry for Primary Industries (MPI) has been operating an eradication program for an incursion of Mycoplasma bovis. Although NZ is still delimiting the outbreak, consideration is being given to how freedom from M. bovis will be demonstrated.

Toward International Harmonization of Breast Implant Registries: International Collaboration of Breast Registry Activities Global Common Data Set.

Background: The Poly Implant Prothèse incident and breast implant-associated anaplastic large cell lymphoma have pointed to the need for uniform registries for breast implants as key features to monitoring the outcomes of breast implant surgeries internationally. The purpose of this study was to identify and harmonize common data elements collected by breast implant registries across the International Collaboration of Breast Registry Activities (ICOBRA) global consortium.

Methods: The authors convened an international group of surgeons, consumers, nurses, registry experts, and regulators to review the data points.

When does diet matter? The roles of larval and adult nutrition in regulating adult size traits in Drosophila melanogaster.

Adult body size is determined by the quality and quantity of nutrients available to animals. In insects, nutrition affects adult size primarily during the nymphal or larval stages. However, measures of adult size like body weight are likely to also change with adult nutrition.