Genetic changes linked to two different syndromic forms of autism enhance reinforcement learning in adolescent male but not female mice.

Unlabelled: Autism Spectrum Disorder (ASD) is characterized by restricted and repetitive behaviors and social differences, both of which may manifest, in part, from underlying differences in corticostriatal circuits and reinforcement learning. Here, we investigated reinforcement learning in mice with mutations in either or , both high-confidence ASD risk genes associated with major syndromic forms of ASD. Using an odor-based two-alternative forced choice (2AFC) task, we tested adolescent mice of both sexes and found male and heterozygote (Het) mice showed enhanced learning performance compared to their wild type (WT) siblings.

Utility of Polygenic Risk Scores (PRSs) in Predicting Pancreatic Cancer: A Systematic Review and Meta-Analysis of Common-Variant and Mixed Scores with Insights into Rare Variant Analysis.

Pancreatic adenocarcinoma is the most common histological subtype of pancreatic cancer, representing approximately 85% of all cases [...

A comparison of objective and subjective measures of physical activity, sedentary and sleep behaviors between persons with and without depressive symptoms.

Background: Major Depressive Disorder (MDD) is characterized by negative recall biases, which may impact how individuals with depressive symptoms report physical activity (PA), sedentary, and sleep behaviors. Additionally, there are discrepancies between subjective and objective behaviors in MDD. Thus, the current study investigated whether individuals with depressive symptoms differ in their subjective and objective PA, sedentary, and sleep behaviors, and whether the magnitude of these discrepancies differ from those in individuals without depressive symptoms.

Interactions of anthropogenic microfibres with the marine macroalga, Ulvalactuca.

Little information exists on the interactions between microfibres (MFs) and marine macroalgae. In this study, the translucent green seaweed, Ulva lactuca, has been exposed to ∼2 mg L suspensions of MFs prepared from dryer lint under controlled conditions, with MFs on the alga surface and remaining in seawater subsequently counted and characterised. MFs were mainly <2 mm and cellulosic, and contained various additives and chemicals used in textile treatment.

Methacrylate-based copolymers as tunable hosts for triplet-triplet annihilation upconversion.

The ability to convert light to higher energies through triplet-triplet annihilation upconversion (TTA-UC) is attractive for a range of applications including solar energy harvesting, bioimaging and anti-counterfeiting. Practical applications require integration of the TTA-UC chromophores within a suitable host, which leads to a compromise between the high upconversion efficiencies achievable in liquids and the durability of solids. Herein, we present a series of methacrylate copolymers as TTA-UC hosts, in which the glass transition temperature ( ), and hence upconversion efficiency can be tuned by varying the co-monomer ratios (-hexyl methacrylate (HMA) and 2,2,2-trifluoroethyl methacrylate (TFEMA)).