Publications by authors named "A E Bugrova"
Article Synopsis
- Accumulation of beta-amyloid peptides (Aβ) and their modifications, particularly phosphorylated serine-8 (pSer8-Aβ), are key factors in the progression of Alzheimer's disease (AD), influencing neuronal degradation and cytotoxicity.* -
- The study found that pSer8-Aβ levels in the brains of 5xFAD mice steadily increase from 3 months to 14-17 months, paralleling the general accumulation of Aβ peptides, and that pSer8-Aβ constitutes up to 1-10% of total Aβ in the cerebrospinal fluid of AD patients.* -
- Mass spectrometry confirmed the possibility of specific Aβ phosphorylation in brain tissues, suggesting
Background/objectives: The development of blood tests for the early detection of individual predisposition to socially significant diseases remains a pressing issue.
Methods: In this pilot study, multiple reaction monitoring mass spectrometry (MRM-MS) with a BAK-270 assay was applied for protein concentrations analysis in blood plasma from 21 healthy volunteers of the European cohort.
Results: The levels of 138 plasma proteins were reliably and precisely quantified in no less than 50% of samples.
Article Synopsis
- Preeclampsia (PE) is a serious pregnancy condition affecting up to 5% of pregnant women, leading to significant health risks for both mothers and newborns, with a need for better early risk assessment methods.
- A study identified ten maternal serum proteins as potential early markers for PE at 11-13 weeks gestation, with most of these proteins having connections to PE from previous research.
- A Support Vector Machine (SVM) model using 19 proteins showed a high predictive power (AUC of 0.91, 87% sensitivity, 95% specificity) for early PE detection, outperforming standard screening methods.
Aim: To identify the features of plasma, platelet hemostasis, and proteomic composition of the blood plasma in patients with acute myocardial infarction (AMI) and healthy volunteers after COVID-19.
Material And Methods: The study included patients with AMI who have recently had COVID-19 (AMI-post-COVID, n=56) and patients with AMI who have not recently had COVID-19 (AMI-control, n=141). Healthy volunteers constituted the control groups and were also divided into control-post-COVID (n=32) and control-control (n=71) groups.
Objectives: The COVID-19 pandemic has exposed a number of key challenges that need to be urgently addressed. Mass spectrometric studies of blood plasma proteomics provide a deep understanding of the relationship between the severe course of infection and activation of specific pathophysiological pathways. Analysis of plasma proteins in whole blood may also be relevant for the pandemic as it requires minimal sample preparation.
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