Publications by authors named "A E Blagov"
The role of metabolic disorders in the development of atherosclerosis.
Cell Mol Biol (Noisy-le-grand)
October 2024
Atherosclerosis is a major risk factor for cardiovascular disease (CVD), which is the leading cause of death worldwide. Atherosclerosis is initiated by endothelial activation, followed by a cascade of events (accumulation of lipids, fibrous elements, and calcification) triggering vasoconstriction and activation of inflammatory pathways. This review focuses on the various stages in the development of atherosclerosis, ranging from endothelial dysfunction to plaque rupture.
View Article and Find Full Text PDFActivated neutrophils release neutrophil extracellular traps (NETs), complex structures composed of extracellular genetic material and proteins sourced from the nucleus, granules, and cytoplasm in response to pathogenic inflammatory conditions. These NETs play a crucial role in the host's innate immune defense against invasive infections. Notably, in conditions like atherosclerosis, these extracellular formations can also be elicited by inflammatory stimuli such as lipids, prothrombotic factors, platelet aggregation, or proinflammatory cytokines.
View Article and Find Full Text PDFArticle Synopsis
- - Oxidative stress occurs when the production of reactive oxidant species exceeds the body's antioxidant defenses, leading to damage in biomolecules, disrupted cell signaling, and increased cell death, impacting chronic diseases like cardiovascular issues, diabetes, and cancer.
- - The link between oxidative stress and chronic inflammation is significant, with each condition potentially promoting the other, highlighting the need for effective treatments despite some unsuccessful antioxidant trials.
- - There is ongoing research into natural antioxidant compounds and metalloenzymes, such as superoxide dismutase and catalase, which may offer new therapeutic options for managing chronic inflammatory diseases by restoring redox balance and enhancing antioxidant activities.
Influence of antibiotics on the development of mitochondrial dysfunction.
Cell Mol Biol (Noisy-le-grand)
May 2024
Article Synopsis
- - Antibiotics are crucial for treating severe bacterial infections, but their use can lead to serious side effects, particularly as bacteria become resistant to them.
- - A significant side effect is the disruption of homeostasis and mitochondrial function in the body, which needs more research to fully understand its implications.
- - The text explores the interaction between antibiotics and mitochondria, outlining strategies that cause dysfunction while also discussing potential solutions and ways to potentially harness these effects beneficially.
Disruption of lipoprotein metabolism plays an important role in the development of several cardiovascular, inflammatory, and metabolic diseases. This review examines the importance of different types of lipoproteins and the role they play in the development of dyslipidemia in obesity. The causes and consequences associated with the disruption of lipid metabolism and its significance in the pathogenesis of obesity are considered.
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