Publications by authors named "A E Berkovich"
To prepare novel biodegradable copolymers with functional substituents that are distributed statistically or randomly over the macromolecule chain and have improved characteristics compared to homopolymers, we conducted a series of synthetic experiments with a novel cyclic monomer, 5-(benzyloxy)-1,3-dioxepan-2-one (). This compound was synthesized, and its homopolymer, as well as its copolymers with L-lactide, ε-caprolactone and trimethylene carbonate, were prepared in a polymerization solution with stannous octoate as the initiator. The formation of the copolymers was confirmed using NMR spectroscopy and DSC data.
View Article and Find Full Text PDFThis review highlights operational principles, features, and modern aspects of the development of third-generation sequencing technology of biopolymers focusing on the nucleic acids analysis, namely the nanopore sequencing system. Basics of the method and technical solutions used for its realization are considered, from the first works showing the possibility of creation of these systems to the easy-to-handle procedure developed by Oxford Nanopore Technologies company. Moreover, this review focuses on applications, which were developed and realized using equipment developed by the Oxford Nanopore Technologies, including assembly of whole genomes, methagenomics, direct analysis of the presence of modified bases.
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- Postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery, linked to higher mortality and complications, but the long-term recurrence rate is not well-understood.
- The study followed 22 patients with POAF, using either an implanted loop recorder or ECG monitoring to track AF recurrence over two years, finding about 35.7% experienced recurrence.
- Results showed no significant difference between monitoring methods, with patients receiving anticoagulation treatment, and no major adverse events like mortality or strokes reported, indicating a need for further research on monitoring methods in this patient group.*
Article Synopsis
- A new method for creating mixed polymer micelles using amorphous poly-D,L-lactide-block-polyethyleneglycol and crystalline amino-terminated poly-L-lactide significantly reduces the preparation time from several days to just 15-20 minutes through ultrasonication.
- The resulting micelles, approximately 150 nm in size, exhibit low cytotoxicity, high stability in various conditions, and have an average molecular weight of 2.1 × 10 with an aggregation number of 6000.
- They show potential as drug delivery vehicles, effectively encapsulating the antitumor drug paclitaxel with a lethal concentration similar to that found in commercial formulations.
Dendrimers are individual macromolecular compounds having a great potential for biomedical application. The key step of the cell penetration by dendrimers is the interaction with lipid bilayer. Here, the interaction between cationic pyridylphenylene dendrimer of third generation (D) and multicomponent liquid (CL/POPC), solid (CL/DPPC) and cholesterol-containing (CL/POPC/30% Chol) anionic liposomes was investigated by dynamic light scattering, fluorescence spectroscopy, conductometry, calorimetric studies and molecular dynamic (MD) simulations.
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