[Isolation and determination of activity of IgA1 protease from Neisseria meningitidis].

A method of the isolation and purification of IgAl protease from a culture of Neisseria meningitidis serogroup A has been developed. Three inactivated intermediates of the production of the meningococcal vaccine, a culture liquid, as well as a supernatant and sediment obtained by the precipitation of bacterial cells by cetavlon, served as a starting material. The purity of IgA1 protease was determined by SDS-PAGE.

[Treatment efficacy in acute intestinal infections, chronic diseases of the gastrointestinal tract and viral hepatitis B using large doses of Russian Bifidumbacterin-forte].

Until now viral and bacterial acute intestinal infections have a high percent in the whole structure of modern intestinal disorders morbidity. Taking into consideration inefficacy of antibacterial treatment in a number of cases, probiotics with antagonist effect on a wide range of bacteria have found a wide usage. This study proves clinic and morphological efficacy of large doses Bifidumbacterinum forte for the treatment of the diseases mentioned.

[Pathomorphology of the large intestinal mucosa in acute infectious colitis].

634 biopsies of distal colon mucosa from 393 patients with acute intestinal bacterial and viral infections were studied histologically, histochemically and morphometrically. Acute catarrhal or catarrhal-hemorrhagic inflammation was found regardless of the colitis etiology (Shigella, Salmonella, Campylobacter, rotavirus). The most pronounced inflammation was in shigellosis and minimal one in rotavirus infection.

[Augmentin in the clinical picture of infectious diseases].

Augmentin is a new combination manufactured by Smith Kline Beecham (Great Britain). It is composed of amoxycillin and clavulanic acid and has antibacterial activity. Augmentin was used in clinical trials in the therapy of 50 adult patients with suppurations after surgical operations on the organs of the abdominal cavity, general staphylococcal infections, pneumonia and prophylactically during the preoperative period.

[Sensitivity of the pathogen of Campylobacter infection to various antibiotics].

Antibiotic sensitivity of 21 Campylobacter strains isolated from humans, monkeys and birds with diarrhea was assayed and the findings are presented. It was shown that all the isolates were highly sensitive to ofloxacin, pefloxacin, ciprofloxacin, josamycin, pipemidinic acid and amoxyclav (a combination of amoxycillin and clavulanic acid). The predominating majority of the strains were resistant to rifampicin, amoxycillin and phosphomycin.