Changes in the Structure of Amorphous Alloys under Deformation by High-Pressure Torsion and Multiple Rolling.

X-ray diffraction and scanning electron microscopy were used to study changes in the structure of amorphous alloys under deformation by high-pressure torsion and multiple rolling. The change in mean nearest neighbor distance (the radius of the first coordination sphere) under deformation was determined. During deformation, shear bands are formed in amorphous alloys, which are regions of lower density compared to the surrounding undeformed amorphous matrix.

DSP107 combines inhibition of CD47/SIRPα axis with activation of 4-1BB to trigger anticancer immunity.

Background: Treatment of Diffuse Large B Cell Lymphoma (DLBCL) patients with rituximab and the CHOP treatment regimen is associated with frequent intrinsic and acquired resistance. However, treatment with a CD47 monoclonal antibody in combination with rituximab yielded high objective response rates in patients with relapsed/refractory DLBCL in a phase I trial. Here, we report on a new bispecific and fully human fusion protein comprising the extracellular domains of SIRPα and 4-1BBL, termed DSP107, for the treatment of DLBCL.

Thermodynamic approach for the understanding of the kinetics of heat effects induced by structural relaxation of metallic glasses.

We present a novel approach to the understanding of heat effects induced by structural relaxation of metallic glasses. The key idea consists in the application of a general thermodynamic equation for the entropy change due to the evolution of a non-equilibrium part of a complex system. This non-equilibrium part is considered as a defect subsystem of glass and its evolution is governed by local thermoactivated rearrangements with a Gibbs free energy barrier proportional to the high-frequency shear modulus.

Shopping online for children: Is safety a consideration?

Introduction: There has been a significant increase in online purchasing and product safety problems have been identified in e-commerce. This study examines consumer behavior and safety perceptions among parents purchasing child products online.

Method: A mixed methods approach, including focus groups and a survey with parents, identified key characteristics and behaviors.

Relation of the fragility and heat capacity jump in the supercooled liquid region with the shear modulus relaxation in metallic glasses.

Fragility constitutes a major parameter of supercooled liquids. The phenomenological definition of this quantity is related to the rate of a change of the shear viscosityat the glass transition temperature. Although a large number of correlations of the fragility with different properties of metallic glasses were reported, an adequate understanding of its physical nature is still lacking.