Interfacing with the Brain: How Nanotechnology Can Contribute.

Interfacing artificial devices with the human brain is the central goal of neurotechnology. Yet, our imaginations are often limited by currently available paradigms and technologies. Suggestions for brain-machine interfaces have changed over time, along with the available technology.

Safety in treatment: Classical pharmacotherapeutics and new avenues for addressing maternal depression and anxiety during pregnancy.

We aimed to review clinical research on the safety profiles of antidepressant drugs and associations with maternal depression and neonatal outcomes. We focused on neuroendocrine changes during pregnancy and their effects on antidepressant pharmacokinetics. Pregnancy-induced alterations in drug disposition and metabolism impacting mothers and their fetuses are discussed.

Health inequalities in incidence of bacteraemias: a national surveillance and data linkage study, England, 2018 to 2022.

BackgroundHealth inequalities exist globally, but limited data exist on this topic for bacteraemia.AimIn this study we investigated health inequalities surrounding bacteraemia in England, to identify high-risk population groups and areas of intervention.MethodsWe retrospectively analysed English surveillance data between 2018 and 2022 for , species, , and both meticillin-sensitive and resistant (MSSA, MRSA) bacteraemia.

The Shape of Relations to Come: Multidimensional Analyses of Complex Human Behavior.

Science, understood to be the behavior of scientists, falls within the purview of behavior analysis. All scientists use scientific instruments to study a natural phenomenon, and for the behavior analyst, perhaps no tool is more important than the graph used to show changes in level, trend, and variability, and upon which behavior analysts make data-based decisions. Modern behaviorism as we know it dates back to the development of the cumulative recorder first developed in the 1930s.

Identification of two novel non-coding variants in Diamond-Blackfan Anemia Syndrome patients by whole genome sequencing.

Diamond-Blackfan Anemia Syndrome (DBAS) is a rare congenital disorder with variable penetrance and expressivity, characterized by pure red cell aplasia that typically manifests as early-onset chronic macrocytic or normocytic anemia and is often associated with other congenital anomalies. DBAS is etiologically heterogeneous, with over 20 known DBAS-associated genes encoding small and large ribosomal protein subunits, and an inheritance pattern largely as autosomal dominant or sporadic. We report two DBAS cases with prior negative genetic testing, which included targeted gene panels, karyotype analysis, chromosome breakage analysis, and whole exome sequencing (WES).