Background: Hypoxic ischemic encephalopathy remains a significant cause of developmental disability. The standard of care for term infants is hypothermia, which has multifactorial effects. Therapeutic hypothermia upregulates the cold-inducible protein RNA binding motif 3 (RBM3) that is highly expressed in developing and proliferative regions of the brain.
View Article and Find Full Text PDFCholine is an essential nutrient with many roles in brain development and function. Supplementation of choline in early development can have long-lasting benefits. Our experiments aimed to determine the efficacy of choline supplementation in a postnatal day (PND) 10 rat model of neonatal hypoxia ischemia (HI) at term using both male and female rat pups.
View Article and Find Full Text PDFBackground: Chronic kidney disease (CKD) has now become a disease of public health importance. The increased prevalence in the population of patients with end stage renal disease (ESRD) is partly related to the failure of early detection of the pre-clinical stages of the disease and its associated risk factors. This study aimed to determine the prevalence of chronic kidney disease and its associated risk factors in Aiyepe community in Ogun state, south western Nigeria as well as determining the awareness level of the population about CKD.
View Article and Find Full Text PDFBackground: Kano is a metropolis and commercial centre in northern Nigeria; it is highly industrialized. Most of the population does factory work. Purpose.
View Article and Find Full Text PDFBackground: Postherpetic neuralgia is a neuralgia caused by the varicella zoster virus. Its natural history involves slow resolution of the pain syndrome. A subgroup of patients may develop severe, long-lasting pain that does not respond to medical therapy.
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