Publications by authors named "A Duzova"
Congenital thrombotic thrombocytopenic purpura (cTTP), which is associated with mutations in the gene for a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 (ADAMTS13), is a chronic and lifelong disease. The clinical course is variable. Regularly using ADAMTS13-containing products such as fresh frozen plasma (FFP) for long-term prophylaxis is the most important treatment to prevent thrombotic microangiopathy (TMA) episodes.
View Article and Find Full Text PDFThe coronavirus disease 2019 (COVID-19) pandemic, instigated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has profoundly impacted healthcare infrastructures around the globe. While children are usually asymptomatic or have mild symptoms, children with pre-existing kidney conditions require specialized attention. This pivotal report, championed by the International Pediatric Nephrology Association (IPNA), delivers precise and actionable recommendations tailored for pediatric patients with kidney ailments in this pandemic landscape.
View Article and Find Full Text PDFIntroduction: Data on age-related differences in rejection rates, infectious episodes, and tacrolimus exposure in pediatric kidney transplant recipients (pKTRs) on a tacrolimus-based immunosuppressive regimen are scarce.
Methods: We performed a large-scale analysis of 802 pKTRs from the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN) registry from 40 centers in 14 countries. The inclusion criteria were a tacrolimus-based immunosuppressive regimen and at least 2 years of follow-up.
Article Synopsis
- Short bowel syndrome (SBS) results from significant small intestine removal, leading to issues like diarrhea and difficulties with drug absorption, which can complicate kidney transplantation.* -
- A case study is presented of an 18-month-old boy with SBS who successfully underwent kidney transplantation and maintained good health for four years without needing intestinal surgery.* -
- The immunosuppressive treatment using prednisolone, tacrolimus, and mycophenolate mofetil worked effectively in this patient, suggesting these drugs are viable options for others with SBS undergoing transplantation.*
Article Synopsis
- The lack of standardized definitions for clinical trial endpoints in pediatric kidney diseases makes it difficult to assess the effectiveness of treatments, particularly for steroid-resistant nephrotic syndrome (SRNS).
- SRNS is challenging to manage, often leading to kidney failure despite current therapies having low cure rates.
- An international group has developed standardized definitions for trial outcomes in SRNS, focusing on measurements like urine protein/creatinine ratios and estimated glomerular filtration rates to better evaluate treatment effectiveness.