Distinctive serum miRNA profile in mouse models of striated muscular pathologies.

Biomarkers are critically important for disease diagnosis and monitoring. In particular, close monitoring of disease evolution is eminently required for the evaluation of therapeutic treatments. Classical monitoring methods in muscular dystrophies are largely based on histological and molecular analyses of muscle biopsies.

Maximal aerobic power in patients with chronic low back pain: a comparison with healthy subjects.

The objective of the study was to compare the maximal aerobic capacity of patients with chronic low back pain with healthy asymptomatic controls matched for age, gender and level of physical activity at work and during sports activities. Reported data in the literature with respect to aerobic capacity in patients with chronic low back pain are not conclusive. Nevertheless, based on the assumption that chronic low back pain leads to deconditioning, physical training programs are widely used as a treatment.

Blunting effect of hypoxia on the proliferation and differentiation of human primary and rat L6 myoblasts is not counteracted by Epo.

Objectives: The aim of this study was to evaluate whether hypoxia and/or erythropoietin would be able to modulate proliferation/differentiation processes of rat and human myoblasts.

Materials And Methods: Rat L6 and primary human myoblasts were grown in 21% or 1% O(2) in the presence or absence of recombinant human erythropoietin (RhEpo). Presence of erythropoietin receptors (EpoR) was assayed using RT-PCR and Western blotting techniques.

Aerobic fitness and limiting factors of maximal performance in chronic low back pain patients.

Background: Studies of measurement of maximal aerobic uptake in patients with chronic low back pain have shown inconsistent results and none has focused on clinical endpoints of ergometry tests.

Objective: To determine the level of cardiorespiratory fitness and to establish factors limiting the maximal effort during the ergometry.

Methods: Patients with chronic low back pain performed a graded maximal exercise test.

A new non exercise-based VO2max prediction equation for patients with chronic low back pain.

Unlabelled: INTRODUCTION The measurement of the maximal oxygen uptake as a parameter of cardiorespiratory fitness is useful in exercise prescription in functional restoration programs but this measurement requires the subject's maximal exertion which is not always possible in patients with chronic low back pain. The purpose of this study was to develop a regression equation to predict maximal oxygen uptake based on non-exercise data in adult patients with chronic low back pain.

Methods: Cross sectional study in which 70 participants completed a maximal graded exercise test in cycle ergometer to assess maximal oxygen uptake.