Publications by authors named "A Duschl"
Article Synopsis
- Endotoxins (lipopolysaccharides) from Gram-negative bacteria can trigger severe immune responses, necessitating strict limits on their presence in injectable drugs, leading to the need for effective removal systems.
- Most current endotoxin removal methods are non-specific, which can accidentally remove important proteins from drug formulations, causing issues in efficacy.
- This study introduces anti-Lipid A antibody-conjugated microparticles that selectively target and remove endotoxins without losing essential proteins, demonstrating higher recovery rates in various formulations compared to traditional non-specific methods.
Article Synopsis
- - The increasing use of nanomaterials in consumer products, particularly cosmetics, raises safety concerns as nanoparticles can easily penetrate biological barriers and interact with allergens, potentially affecting immune responses.
- - This study focuses on how silica nanoparticles interact with the birch pollen allergen Bet v 1, examining key immunotoxicity events in human immune cells, such as allergen uptake and presentation.
- - Results show that when allergens interact with silica nanoparticles, it leads to enhanced immune responses that favor a type 1 inflammatory profile, suggesting that this interaction may reduce allergic sensitization rather than worsen it.
Sodium citrate-stabilized gold nanoparticles (AuNPs) are destabilized when dispersed in cell culture media (CCMs). This may promote their aggregation and subsequent sedimentation, or under the proper conditions, their interaction with dispersed proteins can lead to the formation of a NP-stabilizing protein corona. CCMs are ionic solutions that contain growth substances which are typically supplemented, in addition to serum, with different substances such as dyes, antioxidants, and antibiotics.
View Article and Find Full Text PDFSilica nanoparticles (SiNPs) are generally regarded as safe and may represent an attractive carrier platform for nanomedical applications when loaded with biopharmaceuticals. Surface functionalization by different chemistries may help to optimize protein loading and may further impact uptake into the targeted tissues or cells, however, it may also alter the immunologic profile of the carrier system. In order to circumvent side effects, novel carrier candidates need to be tested thoroughly, early in their development stage within the pharmaceutical innovation pipeline, for their potential to activate or modify the immune response.
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