Publications by authors named "A Durkan"
Purpose: Platinum-based chemotherapy is a mainstay of treatment for many childhood cancers but is associated with acute nephrotoxicity and long-term ototoxicity. There is emerging evidence of long-term renal complications. This study aimed to assess the prevalence of chronic kidney disease (CKD) in children treated with platinum chemotherapy (cisplatin and carboplatin) and identify potential risk factors for the development of CKD.
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- The study investigated how perioperative management affects early kidney graft function in pediatric patients who received living donor kidney transplants.
- Data was collected from two pediatric centers in New South Wales, Australia, analyzing early graft function through estimated glomerular filtration rate (eGFR) at 7 days and 1 month post-transplant.
- Despite managing fluid levels and blood pressure during and after surgery, the findings revealed that these factors did not significantly influence early graft function in the analyzed patients.
HLA donor specific antibodies (DSA) are implicated in antibody-mediated rejection (AMR), graft dysfunction and failure in kidney transplant (KT) recipients. Non-HLA antibodies including angiotensin II type 1 receptor (AT1R) may also play a role in AMR, impact graft function and survival. Data is limited in paediatric KT cohorts.
View Article and Find Full Text PDFPuromycin-sensitive aminopeptidases have long been implicated in cell-cycle regulation, but the mechanism remains unknown. Here we show that mutations in the gene encoding the puromycin-sensitive aminopeptidase, PAM-1 , cause chromosome segregation defects and an elongated mitosis in the one-cell embryo. Depleting a known regulator of the spindle assembly checkpoint (SAC), MDF-2 (MAD2 in humans), restores normal mitotic timing to mutants but exacerbates the chromosome segregation defects.
View Article and Find Full Text PDFOutcome of immunosuppression in children with IgA vasculitis-related nephritis.
Nephrol Dial Transplant
July 2024
Article Synopsis
- Immunoglobulin A vasculitis with nephritis (IgAVN) is the most common vasculitis in children, and this study aimed to analyze clinical outcomes, treatments, and risk factors in a large cohort of 1148 children diagnosed with the condition.
- The retrospective analysis revealed that poorer outcomes were associated with factors like older age, lower kidney function at onset, hypertension, and certain kidney damage features, but no specific treatment was found to be more effective than others.
- The study concluded that there is a need for further research and clinical trials to determine effective treatments and improve health outcomes for children with IgAVN.