Publications by authors named "A Dujon"
Article Synopsis
- Peto's paradox reveals that larger and longer-lived species often have lower-than-expected cancer rates, sparking interest in how they achieve cancer resistance despite traits that might suggest higher risks.
- The research suggests shifting focus to other species with characteristics that increase cancer risk but still show unexpected resistance, aiming to discover potential therapies for humans.
- The study emphasizes the need to consider species that balance cancer risks and defenses while addressing challenges posed by human activities, and suggests that examining transmissible cancers could provide insights into natural suppression of cancer spread.
While it is recognised that most, if not all, multicellular organisms harbour neoplastic processes within their bodies, the timing of when these undesirable cell proliferations are most likely to occur and progress throughout the organism's lifetime remains only partially documented. Due to the different mechanisms implicated in tumourigenesis, it is highly unlikely that this probability remains constant at all times and stages of life. In this article, we summarise what is known about this variation, considering the roles of age, season and circadian rhythm.
View Article and Find Full Text PDFA new perspective on tumor progression: Evolution via selection for function.
Evol Med Public Health
September 2024
Article Synopsis
- - Tumorigenesis is often linked to Darwinian processes like natural selection, but advancing tumors also need the right group phenotypic composition (GPC) to thrive.
- - The selective processes affecting tumor GPCs differ from classical natural selection because tumors aren't true evolutionary individuals and lack heritable fitness variation.
- - The authors suggest that it's misleading to view tumorigenesis solely through a Darwinian lens; instead, understanding cancer progression requires recognizing that genetic and phenotypic diversity contributes to tumor success through a process known as "selection for function."