Publications by authors named "A Duits"
In the PSMAfore randomized controlled trial patients with chemotherapy naïve castrate resistant metastasized prostate cancer (CRPC) progressing after one line of a second-generation androgen receptor signaling inhibitor (ARSI) were randomized to the experimental arm of lutetium-177 PSMA-617 or the control arm of another ARSI. The trial showed an increase in the primary endpoint radiographic progression free survival in the experimental arm. Previously, the VISION trial led to the approval of lutetium-177 PSMA-617 in patients with CRPC progressing after at least 1 second generation ARSI and at least 1 line of chemotherapy with a taxane.
View Article and Find Full Text PDFBackground: Huntington's disease (HD) poses significant challenges for both affected individuals and their informal caregivers. With the progression of HD, caregivers frequently prioritize caring for the person with HD over their own well-being. 'Partner in Balance' (PiB) is an 8-week online self-management program guided by a personal coach, developed to help caregivers of people with HD cope with challenging situations and develop skills to increase resilience and prevent overburdening.
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- Platelet transfusions can transmit infections, but the Mirasol Pathogen Reduction Technology uses riboflavin and UV light to make platelets safer by inactivating pathogens and white blood cells.
- This study reviewed the safety of Mirasol PRPTs given to critically ill infants in a NICU in Curaçao, covering data from February 2016 to April 2023.
- Out of 208 PRPTs given to 46 infants, no significant complications were observed, and although 46% of patients died during the study, these deaths were not associated with the transfusions, indicating that Mirasol PRPTs are safe for use in critically ill neonates.
Autologous bone grafts are commonly used to repair defects in skeletal tissue, however, due to their limited supply there is a clinical need for alternatives. Synthetic ceramics present a promising option but currently lack biological activity to stimulate bone regeneration. One potential approach to address this limitation is the incorporation of immunomodulatory agents.
View Article and Find Full Text PDFObjective: This study aimed to investigate the effectiveness of an adapted ACT intervention (BrainACT) in people who experience anxiety and/or depressive symptoms following acquired brain injury.
Methods: The study is a multicentre randomized controlled two-arm parallel trial. In total, 72 people who survived a stroke or traumatic brain injury were randomized into an eight-session ACT or control (i.