Environment benign synthesis of 5-acyl-4-hydroxypyridin-2(1)-one derivatives as antioxidant and -amylase inhibitors.

Aim: Oxidative stress, caused by postprandial activities, is a major global health issue causing chronic diseases like diabetes mellitus, cancer, and asthma. Therefore, it was envisaged to design and synthesize a series of substituted 4-hydroxypyridine-2(1 h)-ones in order to develop new molecules that can reduce oxidative stress and modulate α-amylase activity also.

Materials & Methods: An environmentally benign, solvent and catalyst free, natural product inspired synthesis of 4-hydroxypyridin-2(1 h)-one derivatives has been developed.

Opalski Syndrome: An Intricate Case of Lateral Medullary Infarction With Unconventional Neurological Features and Diagnostic Challenges.

Opalski syndrome is a rare variant of Wallenberg syndrome characterized by ipsilateral hemiparesis. We present a case involving a 50-year-old male who exhibited symptoms of right-sided upper and lower limb weakness, dizziness, and ataxia. T2-weighted magnetic resonance imaging (MRI) identified an infarction in the right lateral medulla.

Exploring allelochemicals for cleaner and sustainable agriculture: A bibliometric review on research trends, challenges and future prospective.

Allelopathic research is not getting the intended consideration because of the complexities involved in their isolation, identification, understanding their modes of action, interactions with other environmental factors, impacts on non-target organisms and exploration of their utility in diverse fields. Additionally, their variability and trace availability have presented hurdles in establishing future research utilities and their field applications. Exploring the historical context of allelopathic research is essential for obtaining a more profound understanding of the progression in this research domain and to identify the research gaps and potential future prospectives.

Design, Synthesis, Nematicidal Evaluation, and Molecular Docking Study of Pyrano[3,2-]pyridones against .

Root-knot nematodes pose a serious threat to crops by affecting production and quality. Over a period of time, substantial work has been done toward the development of effective and environmentally benign nematicidal compounds. However, due to the inefficiencies of previously reported synthetics in achieving the target of safe, selective, and effective treatment, it is necessary to develop new efficacious and safer nematicidal agents considering human health and environment on top priority.