Publications by authors named "A Dugard"
Objectives: To compare the characteristics of patients with type 2 diabetes mellitus in general practice and those included in randomised controlled trials on which clinical practice guidelines are based.
Design: Cross-sectional comparative study.
Setting: We asked 45 general practitioners from three French Departments to identify the 15 patients with type 2 diabetes mellitus they most recently saw in consultation.
Background: Topical drugs are often used as first-line treatment for dermatological conditions. A within-person design may then be well adapted: it consists of randomizing lesions/body sites rather than patients, which are then concomitantly treated by the different drugs compared, reducing inter-group variability and therefore requiring fewer patients than the classical parallel-group trial.
Objectives: The aim of this review was to provide a methodological overview of within-person randomized trials (WP-RCTs) in dermatology.
Background: Many clinical practice guidelines are based on randomised controlled trials conducted in secondary or tertiary care setting and general practitioners frequently question their relevance for primary care patients. Our aim was to compare the intervention effect estimates between primary care setting randomised controlled trials (PC-RCTs) and secondary or tertiary care setting randomised controlled trials (ST-RCTs).
Methods: Meta-epidemiological study of meta-analyses (MAs) of a binary outcome including at least one PC-RCT and one ST-RCT.
Article Synopsis
- This study investigated the impact of bacteraemia on mortality in critically ill patients with pneumococcal community-acquired pneumonia (CAP) in ICU settings, noting the lack of strong evidence linking bacteraemia to worse outcomes.
- Data was analyzed from a past study (STREPTOGENE) involving 614 immunocompetent adults in France, categorizing patients based on blood culture results for S. pneumoniae to evaluate differences in hospital mortality and other clinical factors.
- Although 274 patients tested positive for bacteraemia and 340 did not, the study found no significant difference in hospital mortality rates, nor did it identify unique prognostic factors for patients with bacteraemia.
Purpose: To assess the relative importance of host and bacterial factors associated with hospital mortality in patients admitted to the intensive care unit (ICU) for pneumococcal community-acquired pneumonia (PCAP).
Methods: Immunocompetent Caucasian ICU patients with PCAP documented by cultures and/or pneumococcal urinary antigen (UAg Sp) test were included in this multicenter prospective study between 2008 and 2012. All pneumococcal strains were serotyped.