Publications by authors named "A Duensing"
Background And Objectives: The standard of care for patients with metastatic hormone-sensitive prostate cancer (mHSPC) includes androgen deprivation therapy (ADT), novel antihormonal therapies (NHT) and/or chemotherapy. Patients with newly diagnosed oligometastatic prostate cancer (omPCa) represent a distinct subgroup of mHSPC, for which the optimal treatment, particularly the role of radical prostatectomy (RP) and metastasis-directed therapy (MDT), is currently under debate.
Materials And Methods: In this single center, retrospective analysis, 43 patients with newly diagnosed omPCa were included.
Background: Spatial biology is an emerging concept to interrogate tumor heterogeneity. The NanoString GeoMx® Digital Spatial Profiling (DSP) platform has become increasingly available. It combines high-plex analysis of protein or messenger RNA expression using barcoded antibodies or oligonucleotide probes with investigator-driven selection of regions of interest.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to explore how mesenchymal stem cell (MSC) lipid metabolism and maternal factors, aside from body mass, might impact the risk of obesity in children.
- Researchers analyzed MSCs from infants of mothers with obesity or normal weight, using techniques like lipidomics and measuring various metabolic indicators during pregnancy.
- Findings revealed distinct MSC clusters linked to maternal metabolic health, suggesting that these clusters could potentially forecast child obesity at a young age, although further validation is needed.
Article Synopsis
- Prostate cancer has different types of cancer cells that can act in various ways, and scientists are trying to understand how these cells are located within a tumor.
- Researchers used a special technique to look at 47 proteins in different parts of tumors from five patients to see how they behave.
- They found that a protein called BAD was more active in the center of tumors and this high activity might help the cancer grow faster; patients with high BAD levels had a shorter time before their cancer came back.
Introduction: Clear cell Renal Cell Carcinoma (ccRCC) has a poor prognosis once metastatic. However, certain metastatic sites have been reported to have a different impact on the patient prognosis. For example, patients with pancreatic metastases have a much more favorable prognosis than those with metastases to other organs.
View Article and Find Full Text PDF