Publications by authors named "A Ducournau"
Increasing rates of (B) and (N) in human and erythromycin-resistant isolates between 2018 and 2023 in France.
Antimicrob Agents Chemother
December 2024
Macrolides are the first-line compounds used for the treatment of campylobacteriosis. Macrolide resistance remains low in France, with mutations in being the main associated resistance mechanism. However, two erythromycin methyltransferases have also been identified(B), which is mainly described in animal reservoirs, and (N), which is strictly described in humans.
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- - This study reports the first isolation of a newly identified bacteria species from two patients in France suffering from gastroenteritis, using samples collected in 2020 and 2022.
- - Both isolates were confirmed to belong to the same species through various methods including biochemical tests, electron microscopy, and genetic analyses, and they exhibited significant cytopathogenic activity in human intestinal cells.
- - The findings highlight the importance of utilizing next-generation sequencing for accurate species identification. It underscores the need to recognize emerging pathogens like this new species as potential foodborne threats to public health.
Article Synopsis
- A young woman was diagnosed with a disseminated Yersinia enterocolitica infection, which presented as pseudoappendicitis, mesenteric lymph node involvement, joint pain, glomerulonephritis, and hepatitis.
- The diagnosis was confirmed using the Western Blot method to detect specific Yersinia antibodies.
- Additionally, the patient exhibited Sweet's syndrome, a rare skin condition linked to autoimmune responses following infections, highlighting unusual skin manifestations in Yersinia enterocolitica cases.
Resistance in to tetracycline is rare. We describe the case of an strain with a high level of resistance to tetracycline (minimum inhibitory concentration = 12 mg/L). However, despite tetracycline resistance, bismuth quadritherapy was effective.
View Article and Find Full Text PDFIntroduction: Aminopenicillins resistance among and strains is associated with a single mutation in the promoting region of a chromosomal beta-lactamase , allowing its expression. Clavulanic acid is used to restore aminopenicillins activity in case of expression and has also an inherent antimicrobial activity over spp. Resistance to amoxicillin-clavulanic acid is therefore extremely rare among these species: only 0.
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