Publications by authors named "A Duc"
Diagnostic role of urine human epididymis protein 4 in ovarian cancer.
Biochem Med (Zagreb)
October 2024
Article Synopsis
- - Ovarian cancer is the most deadly gynecological cancer, often diagnosed late due to non-specific symptoms and ineffective diagnostic methods.
- - This review focuses on human epididymis protein 4 (HE4), which is overexpressed in ovarian cancer and discusses the laboratory techniques for detecting HE4 in urine.
- - Urine HE4 shows potential as a non-invasive tumor marker for ovarian cancer detection, monitoring, and assessing treatment response, but standardized detection methods are essential for clinical use.
Background: , and rearrangements occur, respectively, in 5%, 2%, and 1% non-small cell lung cancers (NSCLC). ALK and ROS1 fusion proteins detection by immunohistochemistry (IHC) has been validated for rapid patient screening, but fusions need to be confirmed by another technique and no RET IHC test is available for clinical use.
Research Design And Methods: We report herein the usefulness of the HTG EdgeSeq Assay, an RNA extraction-free test combining a quantitative nuclease protection assay with NGS, for the detection of , and fusions from 'real-life' small NSCLC samples.
30-and 90-day readmissions in lumbar spine surgery. Differences in prevalence and causes.
Clin Neurol Neurosurg
November 2023
Background: The morbidity associated with surgical treatment of lumbar degenerative conditions has attracted increasing interest due to the economic impact on society, especially postoperative readmission. Limited studies have assessed this risk in a prospective, single-center consecutive fashion.
Objective: To assess the incidence and causes of 30- and 90-day unplanned readmission and revision surgery following surgical treatment for lumbar degenerative spine conditions at a tertiary treatment center.
Extracellular urinary microRNAs as non-invasive biomarkers of endometrial and ovarian cancer.
J Cancer Res Clin Oncol
August 2023
Introduction: Gynecological cancers account for a large number of cancer-related deaths in women. Endometrial cancer is the most prevalent, while ovarian cancer is the deadliest gynecological cancer worldwide. To overcome the clinical need for easy and rapid testing, there is a growing interest in cancer detection in non-invasive modalities.
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- Ovarian cancer is the most lethal gynecological cancer, often diagnosed late due to vague symptoms and ineffective diagnostic methods, highlighting the need for new approaches.
- This study focuses on developing DNA-based aptamers that can detect the ovarian cancer biomarker HE4 in urine, which is overexpressed in cancer but not in healthy individuals.
- Two specific aptamers, AHE1 and AHE3, were successfully created and demonstrated a strong ability to bind to HE4 protein in urine, suggesting they could be valuable for future non-invasive diagnostic tests for ovarian cancer.