Comparison of Flunixin Meglumine, Meloxicam and Ketoprofen on Mild Visceral Post-Operative Pain in Horses.

The analgesic efficacy of meloxicam and ketoprofen against equine visceral pain is unclear. The aim of this study was to compare the analgesic efficacy of meloxicam (M) and ketoprofen (K) to flunixin meglumine (F) following inguinal castration. Horses undergoing inguinal castration under general anesthesia were randomly assigned F (1.

Shielding disk position in intra-operative electron radiotherapy (IOERT): A Monte Carlo study.

Purpose: In IOERT breast treatments, a shielding disk is frequently used to protect the underlying healthy structures. The disk is usually composed of two materials, a low-Z material intended to be oriented towards the beam and a high-Z material. As tissues are repositioned around the shield before treatment, the disk is no longer visible and its correct alignment with respect to the beam is guaranteed.

Neutron H*(10) inside a proton therapy facility: comparison between Monte Carlo simulations and WENDI-2 measurements.

Inside an IBA proton therapy centre, secondary neutrons are produced due to nuclear interactions of the proton beam with matter mainly inside the cyclotron, the beam line, the treatment nozzle and the patient. Accurate measurements of the neutron ambient dose equivalent H*(10) in such a facility require the use of a detector that has a good sensitivity for neutrons ranging from thermal energies up to 230 MeV, such as for instance the WENDI-2 detector. WENDI-2 measurements have been performed at the Westdeutsches Protonentherapiezentrum Essen, at several positions around the cyclotron room and around a gantry treatment room operated in two different beam delivery modes: Pencil Beam Scanning and Double Scattering.

Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.

Structural and biochemical studies of the orf12 gene product (ORF12) from the clavulanic acid (CA) biosynthesis gene cluster are described. Sequence and crystallographic analyses reveal two domains: a C-terminal penicillin-binding protein (PBP)/β-lactamase-type fold with highest structural similarity to the class A β-lactamases fused to an N-terminal domain with a fold similar to steroid isomerases and polyketide cyclases. The C-terminal domain of ORF12 did not show β-lactamase or PBP activity for the substrates tested, but did show low-level esterase activity towards 3'-O-acetyl cephalosporins and a thioester substrate.

Comparing Geant4 hadronic models for the WENDI-II rem meter response function.

The WENDI-II rem meter is one of the most popular neutron dosemeters used to assess a useful quantity of radiation protection, namely the ambient dose equivalent. This is due to its high sensitivity and its energy response that approximately follows the conversion function between neutron fluence and ambient dose equivalent in the range of thermal to 5 GeV. The simulation of the WENDI-II response function with the Geant4 toolkit is then perfectly suited to compare low- and high-energy hadronic models provided by this Monte Carlo code.