Publications by authors named "A Drougard"

Article Synopsis
  • * Increased levels of palmitate from the HFD activate microglia, promoting changes in their metabolism that enhance energy production through aerobic glycolysis, observable within 12 hours of HFD exposure.
  • * Microglia help process harmful fatty acids and provide protective metabolites to surrounding brain cells, showing that short-term high-fat intake can have unexpected positive effects on spatial learning and memory.
View Article and Find Full Text PDF

Background: Despite great advances in proliferative diabetic retinopathy (PDR) therapy over the last decades, one third of treated patients continue to lose vision. While resident vitreous macrophages called hyalocytes have been implicated in the pathophysiology of vitreoretinal proliferative disease previously, little is known about their exact role in PDR. In this study, we address molecular and cellular alterations in the vitreous of PDR patients as a means towards assessing the potential contribution of hyalocytes to disease pathogenesis.

View Article and Find Full Text PDF
Article Synopsis
  • DNA mutations play a crucial role in cancer, but only a few mutated cells lead to the actual disease, and the reasons behind this are not fully understood.
  • A study reveals that variations in early life epigenetics can create different cancer-risk states in adulthood, detectable as early as 10 days old.
  • These risk states show unique DNA methylation patterns linked to genes that are commonly mutated in cancers and associated with worse outcomes, suggesting that early biological differences can influence long-term cancer risk.
View Article and Find Full Text PDF

Chronic high-fat feeding triggers chronic metabolic dysfunction including obesity, insulin resistance, and diabetes. How high-fat intake first triggers these pathophysiological states remains unknown. Here, we identify an acute microglial metabolic response that rapidly translates intake of high-fat diet (HFD) to a surprisingly beneficial effect on metabolism and spatial / learning memory.

View Article and Find Full Text PDF

Proopiomelanocortin (POMC) neurons are critical sensors of nutrient availability implicated in energy balance and glucose metabolism control. However, the precise mechanisms underlying nutrient sensing in POMC neurons remain incompletely understood. We show that mitochondrial dynamics mediated by Mitofusin 1 (MFN1) in POMC neurons couple nutrient sensing with systemic glucose metabolism.

View Article and Find Full Text PDF