Publications by authors named "A Dregan"
Article Synopsis
- A systematic review and meta-analysis examined the mortality risk from infectious diseases (excluding COVID-19) in individuals with severe mental illness (SMI) like schizophrenia and bipolar disorder.
- The analysis included 29 studies, revealing that those with SMI are more than twice as likely to die from any infectious disease and over three times more likely to die from respiratory infections compared to the general population.
- Variations in findings were influenced by factors such as the specific SMI diagnosis, gender, and the type of infection studied.
Background: To prospectively examine whether depressive symptoms were associated with higher risks of incident cardiovascular diseases (CVD) in individuals with type 2 diabetes.
Methods: Included were 17,031 participants from UK Biobank with type 2 diabetes who were free of depression (identified by self-reported medical history, hospital record, and antidepressant use), and composite CVD, including atherosclerotic cardiovascular disease (ASCVD) and heart failure (HF). Cox proportional hazards models were applied to examine the association between depressive symptoms measured by Patient Health Questionaire-2 (PHQ-2) and incident composite CVD and its subtypes, adjusting for potential confounders.
Article Synopsis
- The study examines long-term mortality trends in individuals with schizophrenia-spectrum and bipolar disorders, including the impact of the COVID-19 pandemic.
- It found that standardized mortality ratios for these individuals were more than double the average, increasing significantly during the pandemic, particularly for those with psychiatric comorbidities.
- Additionally, elevated mortality rates were noted among minority ethnic groups, highlighting the need for interventions addressing broader social health determinants.
Background/objectives: The association between egg consumption and dementia is unclear. We carried out a population-based case-control study in China to determine the independent association of egg consumption with dementia.
Methods: We randomly recruited 233 participants with dementia and 233 without dementia from the community health service clinics and the dementia management system in Guangzhou, China to examine their dietary intakes over the past two years and other risk factors for chronic diseases.
Prospective study of bipolar disorder and neurodegenerative diseases.
NPJ Parkinsons Dis
October 2024
Article Synopsis
- - Bipolar disorder (BD) increases the risk of neurodegenerative diseases, including dementia and Parkinson's disease (PD), but the influence of BD medications on this risk is still unclear.
- - A study involving over 500,000 participants found that those with BD had a significantly higher risk for developing dementia (2.52 times) and PD (2.88 times) compared to those without BD.
- - It's suggested that about two-thirds of the relationship between BD and these neurodegenerative diseases might be due to medications used to treat BD, indicating a need for further research on this topic.