Publications by authors named "A Dovrat"

Diabetes leads to many complications; among them is the development of cataract. Hyperglycemia brings to increased polyol concentration in the lens, to glycation of lens proteins, and to elevated level of ROS (Reactive Oxygen Species) causing oxidative stress. The glucose tolerance factor (GTF) was found by several groups to decrease hyperglycemia and oxidative stress both in diabetic animals and humans.

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Epidemiological studies indicated a link between high temperature environment and cataract. The purpose of the study was to investigate if the high temperature in neighborhood bakeries can cause damage to the eye lens. Measurements were done to determine the temperature and exposure time in the neighborhood bakeries during a workday.

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High frequency microwave electromagnetic radiation from mobile phones and other modern devices has the potential to damage eye tissues, but its effect on the lens epithelium is unknown at present. The objective of this study was to investigate the non-thermal effects of high frequency microwave electromagnetic radiation (1.1GHz, 2.

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Our purpose was to investigate the quality and morphology of cultured bovine lenses after exposure to hyperbaric oxygen (HBO) in the presence or absence of desferrioxamine (DFO) or zinc-desferrioxamine (Zn-DFO). Intact bovine lenses were cultured and exposed to HBO of 100% oxygen at 2.5 ATA for 120 min.

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Article Synopsis
  • The study investigated the impact of high partial pressure oxygen on lens quality and enzyme activities (catalase and Na, K-ATPase) in cultured bovine lenses, finding that exposure to hyperbaric oxygen significantly decreased lens optical quality and enzyme activities over a 14-day period.
  • Adding zinc-desferrioxamine (Zn-DFO) before exposure to high oxygen levels largely prevented the damage, while later additions were less effective, indicating Zn-DFO provides a protective effect against oxidative stress.
  • Overall, the research suggests that high oxygen exposure is harmful to lens structure and function, but the timing of Zn-DFO administration is crucial in mitigating these adverse effects, hinting at potential treatments
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