Publications by authors named "A Doubell"
Background: The site-of-disease microbiome and predicted metagenome were evaluated in a cross-sectional study involving people with presumptive tuberculous pericarditis. We also explored the interaction between C-reactive protein (CRP) and the microbiome.
Methods: People with effusions requiring diagnostic pericardiocentesis (n=139) provided pericardial fluid for sequencing and blood for CRP measurement.
Aortic stenosis (AS) is associated with the development of replacement myocardial fibrosis/scar. Given the dose-dependent relationship between scar and clinical outcomes after aortic valve replacement (AVR) surgery, scar quantity may serve as an important risk-stratification tool to aid decision-making on the optimal timing of AVR. Scar is non-invasively assessed and quantified by cardiovascular magnetic resonance (CMR) imaging.
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- A hypertensive crisis significantly increases the risk of cardiovascular events, and this study focuses on understanding myocardial tissue characteristics in patients experiencing this condition using cardiovascular magnetic resonance (CMR) imaging.
- The study analyzed 82 patients—majority had hypertensive emergencies—and found that patients with left ventricular hypertrophy (LVH) presented higher native T1 values and T2 mapping values, indicating potential myocardial edema.
- Results suggested that certain imaging biomarkers such as T1 and T2 mapping could help distinguish between hypertensive emergencies and urgencies, with higher values in emergencies reflecting worse myocardial condition.