Publications by authors named "A Dormoy"
Article Synopsis
- The study investigates how Cushing's syndrome (CS) impacts the gonadotrope axis and testicular functions in men, particularly focusing on the varying effects based on the severity of hypercortisolism and the underlying cause of the syndrome.
- Findings suggest that men with intense hypercortisolism, especially those with paraneoplastic or ectopic ACTH secretion, experience greater impairment in reproductive health, indicated by higher rates of hypogonadotropic hypogonadism and disrupted spermatogenesis.
- This research highlights a gap in understanding the full scope of reproductive impairment in men with CS, which has been under-studied compared to women, despite its potential to worsen related health issues like osteoporosis and myopathy.
Article Synopsis
- * Results showed a significant reduction in median 24-hour urinary free cortisol levels, achieving normal levels in many patients within two weeks, regardless of their treatment history.
- * While osilodrostat improved major clinical symptoms and comorbidities, like hypertension and hyperglycemia, it also led to adrenal insufficiency in 8 out of 33 patients, indicating potential safety concerns.
Objective: Pasireotide is a second-generation somatostatin receptor ligand (SRL) used for treating acromegaly. Its clinical use is limited by adverse effects on glucose homeostasis. The aim of this study was to evaluate longitudinal changes in beta-cell function and insulin sensitivity associated with pasireotide in patients not controlled by first-generation SRLs.
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- The study focuses on the effects of acute graft versus host disease (GVHD) on survival in patients undergoing haploidentical allogeneic stem-cell transplants using peripheral blood stem-cells, supplemented with post-transplant cyclophosphamide.
- It includes data from 131 patients, mainly treated for myeloid malignancies, and shows a significant occurrence of GVHD, particularly grade 2-4 within the first 100 days.
- Importantly, having grade 2 acute GVHD is linked to improved survival rates, leading to a recommendation for further research into GVHD prevention strategies in haplo-transplants combining anti-thymoglobulin and post-transplant cyclophosph
Surgery is the treatment of choice for non-functioning pituitary macroadenomas (NFPAs). In cases of postoperative remnant growth or tumor recurrence, radiotherapy (RT) can be considered. The role of RT in the postoperative management of NFPAs is still debated.
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