Publications by authors named "A Dopazo"
In the mammalian central nervous system, axonal myelination, executed by mature oligodendrocytes (MOLs), enables rapid neural transmission. Conversely, myelin deficiencies are hallmark features of multiple sclerosis, optic neuromyelitis, and some leukodystrophies. Recent studies have highlighted that MOLs are heterogeneous; however, how MOL subpopulations are specified and balanced in physiological settings is poorly understood.
View Article and Find Full Text PDFPurpose: Pancreatic ductal adenocarcinoma (PDAC) has limited treatment options. We compared the efficacy of comprehensive precision medicine against that of the conventional treatment in PDAC.
Patients And Methods: We report a phase III trial of advanced PDAC in which patients were randomized (1:2) to a conventional treatment treated at physician's discretion (arm A) or to precision medicine (arm B).
Article Synopsis
- Alzheimer’s disease (AD) leads to the loss and degeneration of neuronal functions, with specific alterations observed in the axon initial segment (AIS) of affected neurons.
- The study revealed that in APP/PS1 mice, which model AD, there were significant changes in AIS integrity and decreased ankyrinG protein levels, linked to the reduced expression of certain enzymes and proteins in astrocytes.
- Importantly, manipulating retinoic acid levels and using a P2X7 receptor inhibitor showed potential to restore AIS function, suggesting astrocyte involvement in AIS regulation and offering new avenues for early intervention in AD progression.
Extensive genetic studies have elucidated cardiomyocyte differentiation and associated gene networks using single-cell RNA-seq, yet the intricate transcriptional mechanisms governing cardiac conduction system (CCS) development and working cardiomyocyte differentiation remain largely unexplored. Here we show that mice deleted for Dhx36 (encoding the Dhx36 helicase) in the embryonic or neonatal heart develop overt dilated cardiomyopathy, surface ECG alterations related to cardiac impulse propagation, and (in the embryonic heart) a lack of a ventricular conduction system (VCS). Heart snRNA-seq and snATAC-seq reveal the role of Dhx36 in CCS development and in the differentiation of working cardiomyocytes.
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