Publications by authors named "A Don-Wauchope"
Article Synopsis
- - Copeptin is a peptide that responds quickly to stress and is produced alongside arginine vasopressin (AVP), but it has a longer half-life and is more stable than AVP, making it a valuable alternative for measuring the body's stress response.
- - Unlike AVP, copeptin levels are less affected by food intake but can drop with small amounts of oral fluid, which helps provide accurate diagnostic information in various medical conditions, especially those related to body fluid regulation.
- - Copeptin has proven diagnostic utility for conditions like polyuria-polydipsia syndrome, showing high sensitivity and specificity in differentiating causes of AVP resistance and providing more accurate diagnoses compared to traditional methods.
Clinical laboratory professionals have an instrumental role in supporting clinical decision making with the optimal use of laboratory testing for screening, risk stratification, diagnostic, prognostic, treatment selection and monitoring of different states of health and disease. Delivering evidence-based laboratory medicine relies on review of available data and literature. The information derived, supports many national policies to improve patient care through clinical practice guidelines or best practice recommendations.
View Article and Find Full Text PDFAims: Lipids are central in the development of cardiovascular disease, and the present study aimed to characterize variation in lipid profiles across different countries to improve understanding of cardiovascular risk and opportunities for risk-reducing interventions.
Methods And Results: This first collaborative report of the Global Diagnostics Network (GDN) evaluated lipid distributions from nine laboratory organizations providing clinical laboratory testing in 17 countries on five continents. This cross-sectional study assessed aggregated lipid results from patients aged 20-89 years, tested at GDN laboratories, from 2018 through 2020.
The adult bone is continuously being remodelled to repair microdamage, preserve bone strength and mechanical competence as well as maintain calcium homeostasis. Bone turnover markers are products of osteoblasts (bone formation markers) and osteoclasts (bone resorption markers) providing a dynamic assessment of remodelling (turnover). Resorption-specific bone turnover markers are typically degradation products of bone collagen molecules (N- [NTX] and C-telopeptide cross-linked type 1 collagen [CTX]), which are released into the circulation and excreted in urine; or enzymatic activities reflecting osteoclastic resorption, tartrate-resistant acid phosphatase [TRACP].
View Article and Find Full Text PDFObjectives: Verifying new reagent or calibrator lots is crucial for maintaining consistent test performance. The Institute for Quality Management in Healthcare (IQMH) conducted a patterns-of-practice survey and follow-up case study to collect information on lot verification practices in Ontario.
Methods: The survey had 17 multiple-choice questions and was distributed to 183 licensed laboratories.