Publications by authors named "A Dominguez-Mayoral"
Article Synopsis
- NOTCH3cys variants are common and linked to various small vessel diseases, including early-onset stroke and dementia, but there is no comprehensive staging system to assess their severity.
- A cohort study created and validated a simple staging system for NOTCH3-SVD by analyzing data from several international cohorts and the UK Biobank, focusing on the impact of these variants on CVD outcomes and cognition.
- The new system includes 9 disease stages, aiding in understanding the relationship between stages and clinical outcomes like ischemic strokes, cognitive function, and brain damage.
Background: The evolution of ischemic stroke is different accordin'g to sex and is one of the main causes of death in women. Previous studies have shown that women are less likely to receive acute treatment, and stroke center type is an important predictor of door-to-needle times. We investigated whether women are attended in a similar way to men in the telestroke network with specialized stroke physicians.
View Article and Find Full Text PDF: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a hereditary small vessel disease leading to significant morbidity and mortality. Despite advances in genetic diagnosis, the underlying pathophysiology remains incompletely understood. Proteomic studies offer insights into disease mechanisms by identifying altered protein expression patterns.
View Article and Find Full Text PDFObjective: The modified Centers for Disease Control and Prevention (mCDC) criteria have been proposed for diagnosing and managing stroke-associated pneumonia (SAP). The objective was to investigate the impact of SAP on stroke outcome depending on whether or not it conforms to mCDC criteria. Our secondary objective was to identify the responsible factors for antibiotic initiation in stroke patients.
View Article and Find Full Text PDFArticle Synopsis
- Researchers analyzed ischaemic stroke (IS) cases that occurred within eight days of COVID-19 onset to determine if they have a unique genetic background compared to other stroke types.
- Using a method called SUPERGNOVA, they identified specific genomic regions related to large artery atherosclerosis (LAA) and cardioembolic stroke (CES) from a cohort of 73 IS-COV patients and 701 control subjects.
- The study found four genetic loci associated with CES and significant polygenic risk scores for LAA, suggesting IS-COV patients may share genetic traits with these stroke subtypes; more research is needed to see if these traits are specific to viral infection or common in the general population.