Oral transmucosal delivery of eletriptan for neurological diseases.

Migraine is a highly prevalent neurological disease affecting circa 1 billion patients worldwide with severe incapacitating symptoms, which significantly diminishes the quality of life. As self-medication practice, oral administration of triptans is the most common option, despite its relatively slow therapeutic onset and low drug bioavailability. To overcome these issues, here we present, to the best of our knowledge, the first study on the possibility of oral transmucosal delivery of one of the safest triptans, namely eletriptan hydrobromide (EB).

Surgical treatment of a massive bilateral pulmonary embolus due to an entrapped thrombus in a patent foramen ovale: a case report.

Introduction: Entrapped thrombus in a patent foramen ovale is a rare form of right heart thromboembolism. Various treatments have been used, such as anti-coagulation and thrombolytic therapy, vena cava filter, percutaneous thrombectomy and surgical embolectomy.

Case Presentation: A 60-year-old Kosovan woman was admitted to our hospital with a massive bilateral pulmonary thromboembolism, entrapped thrombus in the patent foramen ovale and severe right ventricular dysfunction.

Entrapped thrombus in a foramen ovale causing pulmonary emboli treated with emergent surgery. Literature review.

A 60-year-old woman was admitted due to massive bilateral pulmonary thromboembolism and entrapped thrombus in the patent foramen ovale and severe right ventricular dysfunction. The patient underwent on-pump/beating heart removal of the intracardiac thrombus and bilateral pulmonary embolectomy. The postoperative course was uneventful.

[Multiple nodose shadows of the lungs as a differential diagnosis problem].

In summer 1996, a 31-year-old woman developed arthralgia, subfebrility, and papular efflorescences on the skin, clinically and histologically suspect of vasculitis, to be followed by severe lung edema and anuria, with serum creatinine up to 1182 mol/L in the autumn 1996. The administration of high dose corticosteroids, plasmapheresis and hemodialysis resulted in regression of the clinical symptoms and considerable improvement of the kidney function. Kidney biopsy revealed sclerosing extracapsular glomerulonephritis with extensive fibrocellular crescents.

Artificially induced Trypanosoma brucei brucei infection in Lagune and Borgou cattle in Benin.

Lagune (n = 10) and Borgou (n = 10) cattle of Benin were inoculated subcutaneously with Trypanosoma brucei brucei AnTat, 1.1E. Clinical signs, packed cell volume (PCV), parasitaemia, specific trypanolytic antibodies and haemolytic complement were monitored to evaluate the between-and-within breed variations.