Publications by authors named "A Dofferhoff"
Night sweats are a common symptom. There is a lack of a uniform definition and a diagnostic guideline. In this article we propose a structural analysis for all levels of healthcare.
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- High levels of a specific protein related to vitamin K deficiency were linked to worse outcomes in COVID-19 patients, indicating the potential importance of vitamin K in managing the disease.
- A clinical trial was conducted with 40 hospitalized patients, where half received vitamin K2 supplements and the other half received a placebo, focusing on their impacts on vitamin K status and related health markers.
- Results showed that vitamin K2 supplementation was safe and significantly improved vitamin K status but did not demonstrate a protective effect against the breakdown of elastic fibers in the body.
Background: Pathology during COVID-19 infection arises partly from an excessive inflammatory response with a key role for interleukin (IL)-6. Both vitamin D and K have been proposed as potential modulators of this process.
Methods: We assessed vitamin D and K status by measuring circulating 25-hydroxyvitamin D (25(OH)D) and desphospho-uncarboxylated Matrix Gla-Protein (dp-ucMGP), respectively in 135 hospitalized COVID-19 patients in relation to inflammatory response, elastic fiber degradation and clinical outcomes.
Background: The Netherlands strives for hepatitis C virus (HCV) elimination, in accordance with the World Health Organization targets. An accurate estimate when HCV elimination will be reached is elusive. We have embarked on a nationwide HCV elimination project (CELINE) that allowed us to harvest detailed data on the Dutch HCV epidemic.
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