Publications by authors named "A Djimde"

Background: Malaria remains a significant public health concern, despite global efforts to combat the disease with highest burden in Africa. Reports of emerging artemisinin partial- resistance in East Africa emphasize the importance of molecular data to guide policy decisions. Hence the need for researchers to collaborate with National control programmes to conduct genomics surveillance of malaria to inform malaria control and elimination policies.

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Background: The population structure of the malaria parasite Plasmodium falciparum can reveal underlying adaptive evolutionary processes. Selective pressures to maintain complex genetic backgrounds can encourage inbreeding, producing distinct parasite clusters identifiable by population structure analyses.

Methods: We analysed population structure in 3783 P falciparum genomes from 21 countries across Africa, provided by the MalariaGEN Pf7 dataset.

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Article Synopsis
  • The study investigates the effects of cabamiquine and pyronaridine on the P. falciparum malaria parasite, looking at their performance as standalone treatments and in combination therapy.
  • Using field isolates and a pharmacometrics model, researchers create an interaction map to simulate effective clinical dose ratios for these antimalarials.
  • Results indicate that while pyronaridine alone is less effective, the combination of cabamiquine and pyronaridine significantly improves parasite killing, suggesting the methodology can aid in developing new malaria treatments.
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Background: Mali is known to be a schistosomiasis-endemic country with a limited supply of clean water. This has forced many communities to rely on open freshwater bodies for many human-water contact (HWC) activities. However, the relationship between contact with these water systems and the level of schistosome infection is currently receiving limited attention.

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