Publications by authors named "A Dissanayake"
The development of responsive MRI contrast agents to detect fluctuations in Zn(II) is a growing area of research. Here we describe a high-spin Fe(III) coordination complex, Fe(ADAPT), as one of the first examples of an Fe(III) MRI probe that is responsive to Zn(II). The six-coordinate Fe(ADAPT) contains a phenolate-appended 1,4,7-triazacyclononane (TACN) ligand framework, with the phenolate groups linked to a Zn(II) binding moiety.
View Article and Find Full Text PDFAn octahedral coordination cage with six Fe(III) centers as a MRI probe.
Chem Commun (Camb)
October 2024
The incorporation of multiple Fe(III) centers bridged by rigid ligands into a coordination cage represents a powerful approach for designing effective MRI contrast agents. In this context, an octahedral coordination cage with six high-spin Fe(III) centers is shown to be water soluble, robust towards dissociation and has effective relaxivity as a MRI probe in solution and in mice.
View Article and Find Full Text PDFBackground: The influence of misconceptions and related socio-demographics on metformin use could hamper adherence to medications. This study aimed to assess the rates and causes of metformin non-adherence and to investigate knowledge, attitudes, and practices (KAP) on misconceptions of metformin use including the association with socio-demographic variables.
Methods: An observational analytical cross-sectional study was conducted at the diabetes clinic of Karapitiya Teaching Hospital in Galle, Sri Lanka.
Article Synopsis
- * A bibliometric analysis was conducted to identify the top 100 most cited fungal genera, examining why some have more influence on mycology than others.
- * The paper discusses case studies for these top genera, providing insights into their ecology, economic impact, and key scientific advancements, while also outlining the historical context of research on these fungi.
Article Synopsis
- Malignant struma ovarii (MSO) is an uncommon ovarian tumor mainly made up of thyroid tissue, often spreading to areas like the peritoneum, bones, and lungs.
- A case study involves a woman in her 50s who had a history of ovary removal and presented with a pituitary mass, which was mistakenly thought to be a pituitary tumor but turned out to be metastatic thyroid tissue from MSO.
- After surgery and treatment with radioactive iodine, the patient showed a positive response, with no signs of tumor recurrence or new metastases after five years of monitoring.