Publications by authors named "A Dimakopoulou"
Beyond the debut: unpacking six years of Hypotension Prediction Index software in intraoperative hypotension prevention - a systematic review and meta-analysis.
J Clin Monit Comput
December 2024
Article Synopsis
- Intraoperative hypotension (IOH) during anesthesia can lead to serious complications, and the study examines whether a machine learning tool called the Hypotension Prediction Index (HPI) can help predict and reduce these episodes.
- The systematic review included nine randomized control trials and five cohort studies, revealing that using HPI significantly decreased the average time and incidents of hypotension compared to standard methods.
- Although the findings are promising, the research indicates considerable variability among studies, and further research is needed to determine the clinical implications of using HPI in practice.
Testosterone and other treatments for transgender males and non-binary trans masculine individuals.
Best Pract Res Clin Endocrinol Metab
September 2024
Article Synopsis
- Testosterone therapy is the primary treatment for transmen to help with gender dysphoria, promoting physical masculinization and enhancing quality of life.
- The paper discusses methods of testosterone administration, effects on body systems, health risks, and the importance of ongoing monitoring.
- Continued research on varying testosterone dosages, pregnancy considerations, and older transmen can further optimize treatment approaches.
Metabolic and cardiovascular risks of hormone treatment for transgender individuals.
Best Pract Res Clin Endocrinol Metab
September 2024
Identifying metabolic and cardiovascular risks of gender-affirming hormone therapy (GAHT) is challenging due to other confounding variables that affect patient outcomes and the diversity of treatment regimes. Masculinising hormone therapy produces atherogenic lipid profiles, while effects on other metabolic parameters are not consistent. There is insufficient evidence to conclude if cardiovascular disease risk among transmen is increased.
View Article and Find Full Text PDFThis study explores the previously uncharted territory of the effects of ultraviolet (UV) radiation on diabetic skin, compared to its well-documented impact on normal skin, particularly focusing on carcinogenesis and aging. Employing hairless SKH-hr2, Type 1 and 2 diabetic, and nondiabetic male mice, the research subjected these to UV radiation thrice weekly for eight months. The investigation included comprehensive assessments of photoaging and photocarcinogenesis in diabetic versus normal skin, measuring factors such as hydration, trans-epidermal water loss, elasticity, skin thickness, melanin, sebum content, stratum corneum exfoliation and body weight, alongside photo documentation.
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