Publications by authors named "A Diez-Perez"
Introduction: Impact microindentation (IMI) measures bone material strength index (BMSi) in vivo. However, its ability to predict fractures is still uncertain. This study aimed to determine the association between BMSi and 10 year fracture probability, as calculated by the FRAX algorithm.
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- The primary goal of osteoporosis management is to prevent fractures through individualized, goal-directed treatment plans.
- Effective treatment requires assessing a patient's fracture history, bone mineral density (BMD), and other major risk factors to determine the best course of action.
- Initial treatment should prioritize rapid fracture risk reduction for high-risk patients and take into account the likelihood of meeting BMD targets with either osteoanabolic or antiresorptive therapies.
Impact microindentation (IMI) is a minimally invasive technique that allows the assessment of bone material strength index (BMSi) in vivo, by measuring the depth of a micron-sized, spherical tip into cortical bone that is then indexed to the depth of the tip into a reference material. In this study, we aimed to assess the practicality of its application in 99 women aged 42-84 yr from the Geelong Osteoporosis Study. Impact microindentation was performed in the mid-shaft of the right tibia using the OsteoProbe.
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- A meta-analysis of data from 46 cohorts found that individuals who reported falling in the past year had an increased risk of fractures, highlighting falls as an important factor for fracture risk assessment.
- Previous falls were correlated with a significant rise in fracture risks for both men and women, with hazard ratios indicating that the risk is greater for men.
- The study suggests that falls should be included in the FRAX® algorithm, which currently does not consider this important risk factor for osteoporotic fractures.
Purpose: Bone Material Strength Index (BMSi) quantifies the resistance of bone to a specified force in vivo at the mid tibia using impact microindentation (IMI). Anecdotal evidence suggests that within-participant variance in BMSi may be associated with the individual's mean BMSi. This study aimed to investigate associations between mean and variance of IMI measures in a population-based study.
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