Publications by authors named "A Di Veroli"
Article Synopsis
- The study evaluated the use of frontline TKI therapy in elderly patients (75 years or older) with chronic phase chronic myeloid leukemia (CP-CML) among a large cohort of 332 patients.
- Results showed that 85.8% of patients received imatinib (IM), while 14.2% were treated with second-generation TKIs (2G-TKI) like dasatinib and nilotinib, with a notable percentage starting on reduced doses.
- The findings indicated increased usage of IM after generic versions became available in Italy, but significant discontinuation rates due to resistance and toxicities were observed, highlighting the need for personalized treatment assessments and further studies on lower TKI doses.
Dendritic cells (DCs) are essential orchestrators of immune responses and represent potential targets for immunomodulation in autoimmune diseases. Human amniotic fluid secretome is abundant in immunoregulatory factors, with extracellular vesicles (EVs) being a significant component. However, the impact of these EVs on dendritic cells subsets remain unexplored.
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- - Cystic fibrosis (CF) is a genetic disorder that leads to severe lung issues due to defective CFTR function, inflammation, and infections, making it a major health concern even with new treatments.
- - Researchers are exploring sphingosine-1-phosphate (S1P) lyase (SPL) to target inflammation and fungal infections in CF patients by modifying S1P metabolism, showing promising results in mouse models.
- - They have also conducted drug discovery efforts, successfully identifying two potential inhibitors that could work against both host and pathogen SPL, opening possibilities for new antifungal treatments in CF patients.
Background: Left bundle branch area pacing (LBBAP) is an emerging cardiac pacing modality that preserves fast electrical activation of the ventricles and provides very good electrical measures. Little is known on mechanical ventricular activation during this pacing modality.
Methods: We prospectively enrolled patients receiving LBBAP.
Pulmonary infections (PIs) are a major complication of Acute Myeloid Leukemia (AML) treated with hypomethylating agents (HMA). We retrospectively evaluated 147 AML patients treated frontline with HMA in 2 Centers. Total number of HMA cycles was 1397.
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