Publications by authors named "A Di Silvio"

Article Synopsis
  • Solute carriers (SLCs) are a vast family of over 450 genes important for transporting nutrients and waste in human cells, and they are linked to various diseases such as cancer and diabetes.
  • There is a lack of effective therapeutics targeting SLCs, partly due to challenges in developing reliable screening assays and insufficient information on high-quality SLC-targeting compounds.
  • The RESOLUTE consortium aims to improve this situation by providing a comprehensive resource, including an interactive dashboard that catalogs SLC tool compounds and experimental data to facilitate drug discovery efforts.
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Triticale (×) is a hybrid between wheat ( spp.) and rye (), producing higher grain yields than wheat in challenging environments. Triticale grain is also highly nutritious.

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Aims: To evaluate the feasibility of a transthoracic echocardiogram using an apical-subcostal protocol in invasive mechanical ventilation (IMV) and prone position.

Methods: Prospective study of adults who required a prone position during IMV. A pillow was placed only under the left hemithorax in the prone position to elevate and ease the apical and subcostal windows.

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The FLIPR (Fluorescent Imaging Plate Reader) system has been extensively used in the early stages of drug discovery for the identification of small molecules as a starting point for drug development, and for the pharmacological characterization of compounds. The main application of the system has been the measurement of intracellular Ca(2+) signals using fluorescent calcium indicators.This chapter describes the application of a protocol for the study and characterization of state-dependent blockers of Voltage-Gated Calcium Channels (VGCC) on the FLIPR(TETRA).

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The purpose of this study was to analyze the prognostic and predictive factors that relate to locoregional or distant recurrences in breast cancer patients who have been treated at the National Cancer Institute of Mexico. Multivariate, time-dependent Cox regression analyses indicate that the pN status (positive versus negative lymph node; P = 0.003; HR (hazard ratio), 3.

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