Publications by authors named "A Di Sario"
The imprinted Dlk1-Dio3 domain comprises the developmental genes Dlk1 and Rtl1, which are silenced on the maternal chromosome in different cell types. On this parental chromosome, the domain's imprinting control region activates a polycistron that produces the lncRNA Meg3 and many miRNAs (Mirg) and C/D-box snoRNAs (Rian). Although Meg3 lncRNA is nuclear and associates with the maternal chromosome, it is unknown whether it controls gene repression in cis.
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- - The study examined diagnostic delays in coeliac disease (CD) among 2362 adult patients across 19 Italian clinics, focusing on overall, patient-related, and physician-related delays.
- - The median overall diagnostic delay was found to be 8 months, with patient-associated delays averaging 3 months and physician-associated delays averaging 4 months, linked to previous misdiagnosis and neurological symptoms.
- - The findings highlight the importance of identifying factors that prolong diagnosis, suggesting the need for improved screening strategies for coeliac disease.
Background: Vedolizumab registration trials were the first to include elderly patients with moderate-to-severe ulcerative colitis (UC) or Crohn's disease (CD), but few real-life data have been reported in this population.
Aims: We investigated the effectiveness and safety of vedolizumab in matched cohorts of elderly and nonelderly UC and CD patients.
Methods: The Long-term Italian Vedolizumab Effectiveness (LIVE) study is a retrospective-prospective study including UC and CD patients who started vedolizumab from April 2016 to June 2017.
Article Synopsis
- The study looked at a new treatment called cSEMS for patients who had issues after liver transplants, specifically with narrow connections (anastomotic strictures).
- Researchers examined 91 patients over ten years and found that the treatment worked without serious problems, but some stents moved out of place.
- The main issue was that when the stents migrated, many patients needed more treatments, suggesting that better designs of stents could help prevent this problem.
Article Synopsis
- - Cystic fibrosis (CF) is a genetic disease primarily impacting the lungs and digestive system, and while there's no cure, specialized care has improved life expectancy significantly.
- - The study identified a DNA methylation biomarker that correlates with lung function, body mass index, and severity of CF symptoms, providing a potential tool for monitoring disease and treatment outcomes.
- - Researchers developed a straightforward method for assessing this biomarker and conducted a longitudinal analysis, which could help stratify CF patients for clinical trials in the future.