Platelets as crucial players in the dynamic interplay of inflammation, immunity, and cancer: unveiling new strategies for cancer prevention.

Inflammation plays a critical role in the pathogenesis of various diseases by promoting the acquisition of new functional traits by different cell types. Shared risk factors between cardiovascular disease and cancer, including smoking, obesity, diabetes, high-fat diet, low physical activity, and alcohol consumption, contribute to inflammation linked to platelet activation. Platelets contribute to an inflammatory state by activating various normal cells, such as fibroblasts, immune cells, and vascular cells.

Synergistic photocatalytic degradation of methylene blue and ibuprofen using Co₃O₄-Decorated hexagonal boron nitride (hBN) composites under Sun-like irradiation.

In this study, we report the synthesis and photocatalytic performance of Co₃O₄-decorated hexagonal boron nitride (hBN) composites for degrading methylene blue (MB) and ibuprofen (IBF) under sunlight irradiation. Using a dry impregnation method, the composites were prepared with varying Co₃O₄ loadings (0.5%, 1%, 2%).

Cold atmospheric plasma inactivation of polyphenol oxidase: Focus on the protective and boosting effect of mono- and disaccharides.

Polyphenol oxidase (PPO) is among the most detrimental enzymes in processed plant foods, being responsible for enzymatic browning. To propose a "mild" alternative to traditional enzymatic inactivation methods, this study investigated the effect of cold atmospheric plasma (CAP) on PPO inactivation and highlighted the role of different sugars on both inactivation and structural modification of this enzyme. Different model systems were prepared in phosphate buffer using a purified PPO either alone or added with glucose, fructose, sucrose, and trehalose at different concentrations.

A sulfonimide derivative of bezafibrate as a dual inhibitor of cyclooxygenase-2 and PPARα.

Background: PPARα and cyclooxygenase (COX)-2 are overexpressed in certain types of cancer. Thus, developing a dual inhibitor that targets both could be more effective as an anticancer agent than single inhibitors. We have previously shown that an analog of the bezafibrate named AA520 is a PPARα antagonist.