Publications by authors named "A Di Mario"
Article Synopsis
- Mitochondrial calcium uniporter (MCU) plays a crucial role in calcium uptake and energy metabolism, especially during muscle contractions, but its therapeutic potential in aging-related muscle decline is not well understood.
- Research reveals that the regulator MCUR1 is downregulated in aging muscles, leading to reduced mitochondrial calcium uptake and impaired energy production, contributing to sarcopenia (muscle loss).
- The natural compound oleuropein has been identified as an activator of MCU, which enhances mitochondrial function and endurance in both young and older mice, indicating its potential as a food-derived treatment for age-related muscle dysfunction.
Article Synopsis
- * A 54-gene signature, known as PETsign, correlates with FDG uptake and provides independent prognostic information for patients with luminal breast cancers, the most common subtype.
- * Findings suggest that PETsign reflects metabolic properties of breast cancer cells, predicting higher glucose dependency and involvement of specific signaling pathways, making it useful for improving clinical decisions in treatment.
Obesity is associated with increased risk and worse prognosis of many tumours including those of the breast and of the esophagus. Adipokines released from the peritumoural adipose tissue promote the metastatic potential of cancer cells, suggesting the existence of a crosstalk between the adipose tissue and the surrounding tumour. Mitochondrial Ca signaling contributes to the progression of carcinoma of different origins.
View Article and Find Full Text PDFAim: The aim of this work was to compare lymph node (LN) yield in patients operated on for right colon cancer (RCC) using a laparoscopic approach between those receiving an intracorporeal (ICA) or extracorporeal anastomosis (ECA).
Method: This is a retrospective multicentre study involving patients operated on for RCC in nine tertiary referral centres in Latin America during a 2-year period. The main comparative outcome between groups was the number of LNs harvested between groups.
Objective: Recent studies have pointed to neuroinflammation and neurotrophic factors as crucial mediators in the pathophysiology origins of mood disorders. The aim of this review is to assess the potential association between cognitive impairment, brain imaging abnormalities, and inflammatory biomarkers in patients affected by bipolar disorder (BD).
Method: Following PRISMA (Preferred Reporting Items for Systematic reviews and Meta-analyses) guidelines, we systematically searched PubMed, Google Scholar, Scopus, and Web of Science databases, with no year restriction, up until August 2023, for human studies that examined the relationship between inflammatory markers and cognitive impairment in BD patients.