Publications by authors named "A Di Fonso"
Article Synopsis
- - Store-operated calcium entry (SOCE) is a critical process in cells that helps them maintain calcium levels, especially when internal stores are low, and occurs in specialized regions of skeletal muscle where specific proteins are located.
- - Mutations in certain proteins associated with SOCE are linked to a muscle disorder known as tubular aggregate myopathy, which shows an increase in specific structures as muscles age, particularly in male mice.
- - A study on mice with a muscle-specific knockout of a protein called Orai1 found that these mice had a shorter lifespan, reduced weight, exercise intolerance, and more damaged mitochondria, while also showing changes in muscle structure, including a lack of tubular aggregates with age.
Store-operated Ca entry (SOCE) is a mechanism that allows muscle fibers to recover external Ca, which first enters the cytoplasm and then, via SERCA pump, also refills the depleted intracellular stores (i.e., the sarcoplasmic reticulum, SR).
View Article and Find Full Text PDFAgeing is associated with an increase in the incidence of heart failure, even if the existence of a real age-related cardiomyopathy remains controversial. Effective contraction and relaxation of cardiomyocytes depend on efficient production of ATP (handled by mitochondria) and on proper Ca supply to myofibrils during excitation-contraction (EC) coupling (handled by Ca release units, CRUs). Here, we analyzed mitochondria and CRUs in hearts of adult (4 months old) and aged (≥24 months old) mice.
View Article and Find Full Text PDFRationale: Mutations in the cardiac Ryanodine Receptor gene () cause dominant catecholaminergic polymorphic ventricular tachycardia (CPVT), a leading cause of sudden death in apparently healthy individuals exposed to emotions or physical exercise.
Objective: We investigated the efficacy of allele-specific silencing by RNA interference to prevent CPVT phenotypic manifestations in our dominant CPVT mice model carriers of the heterozygous mutation R4496C in .
Methods And Results: We developed an in vitro mRNA and protein-based assays to screen multiple siRNAs for their ability to selectively silence mutant -R4496C mRNA over the corresponding wild-type allele.
How does early cognitive behavioural therapy reduce postpartum depression?
Clin Exp Obstet Gynecol
July 2015
Postpartum depression (PPD) is a frequent mood disorder. Early identification of mothers at risk is crucial to successful prevention. Cognitive Behavioural Therapy (CBT) is an effective preventing therapy.
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