Publications by authors named "A Di Biagio"
Background: Major adverse cardiovascular events (MACEs) may contribute to the high morbidity in people with four-class drug-resistant HIV (4DR-PWH).
Objectives: To explore the probability of MACEs in 4DR-PWH compared with non-4DR controls.
Methods: This was a retrospective, propensity score-matched cohort study on 4DR-PWH (cases) and non-4DR-PWH (controls), on ART, without previous MACEs.
Article Synopsis
- The study aimed to determine if switching from dolutegravir/abacavir/lamivudine (DTG/ABC/3TC) to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) reduces neuropsychiatric symptoms in HIV patients.
- Conducted as a randomized trial, it involved 41 participants who had been stable on DTG/ABC/3TC and compared those who switched to BIC/FTC/TAF versus those who continued their current therapy.
- Results indicated that switching improved sleep disorders among participants but did not significantly impact other neuropsychiatric symptoms, suggesting better tolerability with BIC-based therapy despite the small sample
Objective: The study aimed to assess the impact of smoking exposure on major clinical events (MCE) in a real-life setting of people living with HIV (PWH).
Design: Observational longitudinal multicentre cohort study from Italy.
Methods: Consecutive 983 PWH were enrolled in "STOP Smoking in HIV people" (STOPSHIV) projects and followed from July 2014 until September 2023.
Article Synopsis
- The study examines T-cell characteristics in individuals with perinatal HIV (PHIV), adults with HIV (AHIV), and healthy controls, focusing on activation, exhaustion, and regulatory T-cell frequencies.
- It involved a cross-sectional analysis of young people with controlled HIV and healthy individuals, using various immunological markers to identify differences between groups.
- Results showed PHIV had a healthier T-cell profile with lower exhaustion markers and higher naive T-cell frequencies than AHIV, suggesting that the timing of HIV infection influences immune system status.
Article Synopsis
- A study looked at people with HIV who had resistance to four types of medicine and found that 12% of them were likely to develop cancer within eight years.
- They discovered that the risk of cancer was higher if a person had more virus in their blood and if they were assigned male at birth.
- The researchers suggested that it's important to focus on keeping the virus levels low and doing regular health checks to prevent cancer in these patients.