Publications by authors named "A Desmarchais"
Background: Bisphenol S (BPS) is the main substitute for bisphenol A (BPA), a well-known plasticiser and endocrine disruptor. BPS disrupts ovarian function in several species. Moreover, a few studies have reported that the effects of BPS might be modulated by the metabolic status, and none have characterised the granulosa cell (GC) proteome after chronic BPS exposure.
View Article and Find Full Text PDFBisphenol (BP) structural analogues of BPA are widely used. Previous studies showed similar effects of BPA and BPS on reproduction in several species including human. We hypothesised that the similar effects of several bisphenols (BPs) could accumulate in granulosa cells (GCs) and affects steroidogenesis.
View Article and Find Full Text PDFBackground: Ovarian granulosa cells (GC) are essential for the development and maturation of a proper oocyte. GC are sensitive to endocrine disruptors, including bisphenol A (BPA) and its analogue bisphenol S (BPS), plasticisers present in everyday consumer products. BPA exhibits greater binding affinity for the membrane oestrogen receptor (GPER) than for the nuclear oestrogen receptors (ERα and ERβ).
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- - The study focuses on the medio-basal hypothalamus (MBH) in sheep, investigating how food restriction influences genes relevant to metabolism and seasonal reproduction, highlighting the link between these two processes.
- - Analyzing a large sample of ewes (120), the research used RNA sequencing and found modest changes in gene expression due to food restriction, affecting around 100 genes with specific increases and decreases in well-known metabolic regulators.
- - The findings suggest that certain genes involved in photoperiodic responses and metabolism within the MBH are influenced by food cues, providing insights that could have implications for understanding similar processes in humans, especially concerning obesity and reproductive health.
Bisphenol S (BPS) affects terminal folliculogenesis by impairing steroidogenesis in granulosa cells from different species. Nevertheless, limited data are available on its effects during basal folliculogenesis. In this study, we evaluate in vitro the effects of a long-term BPS exposure on a model of basal follicular development in a mono-ovulatory species.
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