Publications by authors named "A Desjeux"
Perianal fistulas in Crohn's disease are frequent and disabling, with a major impact on patients' quality of life. Cell-based therapy using mesenchymal stem cells represents new hope for these patients, but long-term efficacy remains challenging. In a pilot study, including patients with refractory complex perianal fistulas, autologous adipose-derived stromal vascular fraction (ADSVF) combined with microfat achieved combined remission in 60% of cases, with a good safety profile at 1 year.
View Article and Find Full Text PDFEndoscopic balloon dilation of colorectal strictures complicating Crohn's disease: a multicenter study.
Clin Res Hepatol Gastroenterol
September 2021
Introduction: While endoscopic balloon dilation (EBD) is widely used to manage ileal strictures, EBD of colorectal strictures remains poorly investigated in Crohn's disease (CD).
Methods: We performed a retrospective study that included all consecutive CD patients who underwent EBD for native or anastomotic colorectal strictures in 9 tertiary centers between 1999 and 2018. Factors associated with EBD failure were also investigated by logistic regression.
Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the reference surgical treatment for patients with ulcerative colitis (UC) refractory to medical treatment. One of the complications is leaving a strip of rectal mucosa which can be a cause of persistent inflammation or cuffitis. The objective of our study is to present an endoscopic approach for the treatment of cuffitis.
View Article and Find Full Text PDFArticle Synopsis
- - A study was conducted to compare the performance of three ELISA kits used for measuring infliximab serum trough levels (s-IFXt) and anti-drug antibodies (ADAb) in 35 patients with inflammatory bowel disease (IBD).
- - Key differences in technical characteristics of the kits were found, impacting the measurement results; Ridascreen® reported s-IFXt levels significantly higher than the other two kits, leading to discrepancies in patient classification.
- - The findings indicate that the assays are not interchangeable for quantitative results, emphasizing the need for consistency in the assay used for monitoring IBD patients to avoid conflicting treatment decisions.
Article Synopsis
- Mesenchymal stem cell therapy shows promise for treating perianal Crohn's fistulas that do not respond to conventional treatments, which are challenging and debilitating.
- A documented case involved a patient who received autologous adipose-derived stromal vascular fraction (ADSVF) and microfat injections, leading to remarkable healing of the fistulas within 12 weeks and sustained improvement at 48 weeks.
- The successful outcome suggests that combining ADSVF and microfat may provide a new effective treatment approach for patients suffering from these complex fistulas associated with Crohn's disease.