PSA testing in primary care: is it time to change our practice?

Background: Historical prostate-specific antigen (PSA)-based screening studies reduced prostate cancer-related deaths but also led to overdiagnosis/overtreatment. Since then, opportunistic PSA testing has increased, and late-stage diagnoses and prostate-cancer related deaths are rising.

Objectives: To review current trends regarding PSA testing in primary care and propose a collaborative approach to improve early prostate cancer detection.

Impact of biological sex, concussion history and sport on baseline NeuroTracker performance in university varsity athletes.

This study aimed to assess the impact of biological sex, concussion history, and type of sport on the baseline NeuroTracker performance, a test/train three-dimensional multiple object tracking paradigm used in sport contexts, in university level varsity athletes. A total of 136 university level varsity athletes participating in male ice hockey, male or female soccer, female volleyball, and mixed biological sex cheerleading underwent preseason NeuroTracker baseline assessments. Significant differences in NeuroTracker performance were observed based on biological sex ( < 0.

Improving the reliability of small- and wide-angle X-ray scattering measurements of anisotropic precipitates in metallic alloys using sample rotation.

Nanometric precipitates in metallic alloys often have highly anisotropic shapes. Given the large grain size and non-random texture typical of these alloys, performing small- and wide-angle X-ray scattering (SAXS/WAXS) measurements on such samples for determining their characteristics (typically size and volume fraction) results in highly anisotropic and irreproducible data. Rotations of flat samples during SAXS/WAXS acquisitions are presented here as a solution to these anisotropy issues.

Influence of device configuration and noise on a machine learning predictor for the selection of nanoparticle small-angle X-ray scattering models.

Small-angle X-ray scattering (SAXS) is a widely used method for nanoparticle characterization. A common approach to analysing nanoparticles in solution by SAXS involves fitting the curve using a parametric model that relates real-space parameters, such as nanoparticle size and electron density, to intensity values in reciprocal space. Selecting the optimal model is a crucial step in terms of analysis quality and can be time-consuming and complex.